{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:58:59Z","timestamp":1772798339006,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this work was to report on the safety and feasibility of warm humidified CO<jats:sub>2<\/jats:sub> (WHCO<jats:sub>2<\/jats:sub>) insufflation during cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ten consecutive patients with histologically confirmed peritoneal cancer were enrolled in this phase I pilot nonrandomized controlled trial. They were alternately assigned to CRS and HIPEC with WHCO<jats:sub>2<\/jats:sub> versus standard procedure. WHCO<jats:sub>2<\/jats:sub> was delivered at 10\u00a0L\/min, a pressure of 4.5\u00a0bar, 37\u00baC and 98% relative humidity during CRS using the HumiGard<jats:sup>TM<\/jats:sup> system. HIPEC was performed with an open abdomen using the Coliseum technique at 42\u00baC for 60\u00a0min. All patients were admitted to the intensive care unit and commenced on total parenteral nutrition postoperatively. Surface and core temperatures were measured every 30\u00a0min using an infrared camera and nasopharyngeal probe, respectively. Clinicopathological, intra\u2010 and postoperative details were collated between groups, and median surface and core temperatures were statistically compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surface and core temperatures were generally higher in the WHCO<jats:sub>2<\/jats:sub> group. Core temperature at 120 and 180\u00a0min was significantly higher in the WHCO<jats:sub>2<\/jats:sub> versus the non\u2010WHCO<jats:sub>2<\/jats:sub> group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028 and 0.008, respectively). There was a significant linear relationship between core and surface temperature at 30, 60, 90, 120, 150 and 180\u00a0min (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.033, 0.004, 0.007, 0.021, 0.009 and 0.006, respectively). The peritoneal cancer index was lower but the estimated blood loss was higher in the non\u2010WHCO<jats:sub>2<\/jats:sub> than the WHCO<jats:sub>2<\/jats:sub> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WHCO<jats:sub>2<\/jats:sub> in CRS and HIPEC appears to be safe and feasible. An appropriately powered phase II trial will be required to determine if WHCO<jats:sub>2<\/jats:sub> is associated with improved intra\u2010 and postoperative outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15588","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:59:21Z","timestamp":1613642361000},"page":"1573-1578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A phase I, nonrandomized controlled trial demonstrating the novel technique of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy utilizing warm humidified carbon dioxide insufflation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-6580","authenticated-orcid":false,"given":"Celine","family":"Garrett","sequence":"first","affiliation":[{"name":"Surgical Outcomes Research Centre Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"School of Medicine Western Sydney University Campbelltown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Steffens","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre Royal Prince Alfred Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila","family":"Ansari","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherry","family":"Koh","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre Royal Prince Alfred Hospital Sydney NSW Australia"},{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney NSW 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Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:01:30Z","timestamp":1693220490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,8]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/codi.15588"],"URL":"https:\/\/doi.org\/10.1111\/codi.15588","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,8]]},"assertion":[{"value":"2020-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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