{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:23:23Z","timestamp":1762543403239,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate long\u2010term changes in patient\u2010reported bowel function from presentation of anal canal squamous cell carcinoma (SCC) successfully treated with the modified Nigro protocol using a patient\u2010reported outcome measure for bowel function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a retrospective study of prospectively collected patient\u2010reported outcomes for bowel function. We included patients that were successfully treated with the modified Nigro protocol for anal SCC and had completed the Colorectal Functional Outcomes (COREFO) questionnaire at presentation, following the modified Nigro treatment (post\u2010Nigro), and at subsequent surveillance visits (medium and long term). We compared the differences in mean domain and total COREFO scores using a paired <jats:italic>t<\/jats:italic> test for each paired time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients met inclusion criteria. Time from completion of the modified Nigro was post\u2010Nigro at 3\u20136\u00a0months, medium\u2010length follow\u2010up at 8\u201312\u00a0months and long\u2010term follow\u2010up at 12\u201318\u00a0months. There was significant improvement in the stool\u2010related aspects domain (pain, bleeding and anal skin irritation) from presentation to our short\u2010 and medium\u2010length follow\u2010up (42.5 to 23.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). There was worsening in the frequency domain in the medium term (7.23 to 14.5, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). There were no differences in any other domain or time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Global bowel function does not appear to change following successful treatment of anal canal SCC with the modified Nigro protocol in the long term. There are some improvements in stool\u2010related aspects and worsening in bowel movement frequency at medium\u2010length follow\u2010up. These findings should help surgeons counsel patients with regard to bowel function expectations for those with anal canal SCC in the long term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15590","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:36:54Z","timestamp":1613641014000},"page":"1480-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term bowel function patient\u2010reported outcomes after successful chemoradiation for carcinoma of the anal canal"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-1020","authenticated-orcid":false,"given":"Robert D.","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Surgery Dartmouth\u2013Hitchcock Medical Center Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Surgery Dartmouth\u2013Hitchcock Medical Center Lebanon New Hampshire USA"},{"name":"VA Outcomes Group VA Quality Scholars Program White River Junction VAMC White River Junction Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Milanese","sequence":"additional","affiliation":[{"name":"Department of Surgery Dartmouth\u2013Hitchcock Medical Center Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-3817","authenticated-orcid":false,"given":"Srinivas J.","family":"Ivatury","sequence":"additional","affiliation":[{"name":"Department of Surgery Dartmouth\u2013Hitchcock Medical Center Lebanon New Hampshire USA"},{"name":"Geisel School of Medicine Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"volume-title":"Cancer Facts and Figures 2020","year":"2020","author":"American Cancer 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aspects of radiation therapy for anal cancer","volume":"5","author":"Scher ED","year":"2014","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2014.30.4.165"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13566-017-0326-3"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001646"}],"container-title":["Colorectal 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