{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:28:47Z","timestamp":1790706527708,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Identification of the risks of postoperative complications may be challenging in older patients with heterogeneous physical and cognitive status. The aim of this multicentre, observational study was to identify variables that affect the outcomes of colon cancer surgery and, especially, to find tools to quantify the risks related to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients aged \u226580\u00a0years with electively operated Stage I\u2013III colon cancer were recruited. The prospectively collected data included comorbidities, results of the onco\u2010geriatric screening tool (G8), Clinical Frailty Scale (CFS), Charlson Comorbidity Index (CCI) and Mini Nutritional Assessment\u2010Short Form (MNA\u2010SF), and operative and postoperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 161 patients (mean 84.5\u00a0years, range 80\u201397, 60% female) were included. History of cerebral stroke (64% vs. 37%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), albumin level 31\u201334\u00a0g\/l compared with \u226535\u00a0g\/l (57% vs. 32%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), CFS 3\u20134 and 5\u20139 compared with CFS 1\u20132 (49% and 47% vs. 16%, respectively) and American Society of Anesthesiologists score &gt;3 (77% vs. 28%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) were related to a higher risk of complications. In multivariate logistic regression analysis CFS \u22653 (OR 6.06, 95% CI 1.88\u201319.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) and albumin level 31\u201334\u00a0g\/l (OR 3.88, 1.61\u20139.38, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) were significantly associated with postoperative complications. Severe complications were more common in patients with chronic obstructive pulmonary disease (43% vs. 13%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047), renal failure (25% vs. 12%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021), albumin level 31\u201334\u00a0g\/l (26% vs. 8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) and CCI &gt;6 (23% vs. 10%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery on physically and cognitively fit aged colon cancer patients with CFS 1\u20132 can lead to excellent operative outcomes similar to those of younger patients. The CFS could be a useful screening tool for predicting postoperative complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15689","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T17:06:10Z","timestamp":1619715970000},"page":"1824-1836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Clinical Frailty Scale is a useful tool for predicting postoperative complications following elective colon cancer surgery at the age of 80 years and above: A prospective, multicentre observational study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-2640","authenticated-orcid":false,"given":"Susanna","family":"Niemel\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere 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