{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:41:25Z","timestamp":1791819685169,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this work was to determine the factors associated with poor wound healing in patients with perianal Crohn's disease (pCD) who had undergone proctectomy in the era of biologic therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Case record review was performed on 103 patients with pCD who underwent proctectomy at St Mark's Hospital, Harrow and the Western General Hospital, Edinburgh between 2005 and 2017. Healing rates at 6 and 12\u00a0months post\u2010proctectomy were considered; univariate analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty out of 103 patients (58.3%) had failure of wound healing at 6\u00a0months and 41\/103 (39.8%) at 12\u00a0months. In total, 63.1% (65\/103) patients received biologic therapies prior to proctectomy; however, exposure to biologics was not a significant factor in predicting failure of wound healing at 12\u00a0months (infliximab <jats:italic>p<\/jats:italic>\u00a0=\u00a00.255; adalimumab <jats:italic>p<\/jats:italic>\u00a0=\u00a00.889; vedolizumab <jats:italic>p<\/jats:italic>\u00a0=\u00a00.153). Male gender was the only variable associated with poor wound healing at 12\u00a0months on univariate analysis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.017). A lower pre\u2010operative C\u2010reactive protein was associated with early wound healing at 6\u00a0months compared with at 12\u00a0months (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041) on univariate analysis. Other parameters not associated with rates of wound healing included smoking status, corticosteroid exposure, thiopurine exposure, number of previous biologics, perianal sepsis on MRI within the last 12\u00a0months, duration of CD prior to proctectomy and pre\u2010operative albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than a third of patients had unhealed wounds 12\u00a0months after proctectomy. We report that unhealed wounds are more common in male patients. Importantly, our results also suggest that exposure to biologics does not affect rates of wound healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15744","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T04:18:20Z","timestamp":1621657100000},"page":"2091-2099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic factors associated with unhealed perineal wounds post\u2010proctectomy for perianal Crohn's disease: a two\u2010centre study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-1192","authenticated-orcid":false,"given":"Rebecca K.","family":"Grant","sequence":"first","affiliation":[{"name":"The Edinburgh IBD Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-7612","authenticated-orcid":false,"given":"Alfonso","family":"Elosua\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Hospital Garc\u00eda Orcoyen Navarra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bouri","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-5752","authenticated-orcid":false,"given":"Kapil","family":"Sahnan","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-0332","authenticated-orcid":false,"given":"William M.","family":"Brindle","sequence":"additional","affiliation":[{"name":"The Edinburgh IBD Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-9916","authenticated-orcid":false,"given":"Stella M.","family":"Dilke","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L. M.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Northwick Park Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel O. A.","family":"Adegbola","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-2833","authenticated-orcid":false,"given":"Janindra H.","family":"Warusavitarne","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Tozer","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D. R.","family":"Arnott","sequence":"additional","affiliation":[{"name":"The Edinburgh IBD Unit Western General Hospital Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailsa L.","family":"Hart","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.6.525"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02603444"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235190"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800610204"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730226"},{"key":"e_1_2_11_11_1","first-page":"1013","article-title":"Long\u2010term complications and prognosis following major surgery for ulcerative colitis","volume":"53","author":"Watts JM","year":"1966","journal-title":"Br J Surg"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800561014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800581102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800650810"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588413X13511609958451"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091339"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586557"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685530500233847"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0355"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3450-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1768-4"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2001.00250.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02092.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12796"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010250"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13356"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182a48505"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316772"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14430"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy131"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:28:13Z","timestamp":1692300493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/codi.15744"],"URL":"https:\/\/doi.org\/10.1111\/codi.15744","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]},"assertion":[{"value":"2020-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}