{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:42:25Z","timestamp":1785530545370,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to describe the dynamic changes in blood work following individual adjusted dosage of intravenously administered iron(III) isomaltoside in a 4\u2010week period prior to surgery in patients with colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010centre, observational cohort study with prospectively collected data, including patients with colorectal cancer receiving preoperative treatment with iron(III) isomaltoside. Blood samples were taken at baseline, 1 week, 2 weeks and 4 weeks after initial treatment. Sixty\u2010two patients were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients were included for final analysis. The mean increase in haemoglobin was 0.77\u00a0g\/dl (95% CI 0.52\u20131.03 g\/dl, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) at week 1, 1.5\u00a0g\/dl (95% CI 1.21\u20131.80 g\/dl, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) at week 2 and 2.13\u00a0g\/dl (95% CI 1.71\u20132.55 g\/dl, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) at week 4. Patients with severe anaemia (&lt;9.02\u00a0g\/dl) showed the largest increase in haemoglobin during the treatment course (2.92\u00a0g\/dl, 95% CI 2.27\u20133.58\u00a0g\/dl, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). Patients with mild anaemia (&gt;10.31\u00a0g\/dl) did not show a significant increase (0.66\u00a0g\/dl, 95% CI \u22120.29\u20131.61 g\/dl, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.17). The mean of transferrin saturation after 4 weeks was 8% (95% CI 6%\u201310%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After intravenously administered iron, patients with severe anaemia had the most substantial increase in haemoglobin, and the increase was largest after 4 weeks. Patients with mild anaemia did not have an increase in haemoglobin during the treatment course. The vast majority of patients still had iron deficiency at surgery 4 weeks after the initial treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15789","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T17:36:14Z","timestamp":1624556174000},"page":"2550-2558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The dynamic effects of preoperative intravenous iron in anaemic patients undergoing surgery for colorectal cancer"],"prefix":"10.1111","volume":"23","author":[{"given":"Rasmus Dahlin","family":"Bojesen","sequence":"first","affiliation":[{"name":"Department of Surgery Slagelse Hospital Slagelse Denmark"},{"name":"Centre for Surgical Science Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Ravn","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Surgery Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-5093","authenticated-orcid":false,"given":"Rasmus Peuliche","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Centre for Surgical Science Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Grube","sequence":"additional","affiliation":[{"name":"Department of Surgery Slagelse Hospital Slagelse Denmark"},{"name":"Centre for Surgical Science Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Lyng","family":"Forman","sequence":"additional","affiliation":[{"name":"Section of Biostatistics Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Gogen\u00fcr","sequence":"additional","affiliation":[{"name":"Centre for Surgical Science Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13110"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61381-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2017.01.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001360"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825b35d5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005033.pub2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60502-X"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.12.041"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10328"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2461-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03508-y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-004-2888-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588407X183364"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31539-7"},{"issue":"4","key":"e_1_2_12_16_1","first-page":"338","article-title":"Intravenous iron administration for postoperative anaemia management after colorectal cancer surgery in clinical practice: a single\u2010centre, retrospective study","volume":"16","author":"Laso\u2010Morales MJ","year":"2018","journal-title":"Blood Transfus"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6688"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401038"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.12.029"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001646"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12601"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12651"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i8.1972"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_12_26_1","unstructured":"The Danish Health Authority.National clinical guideline for transfusion using blood components.https:\/\/www.sst.dk\/da\/udgivelser\/2018\/~\/media\/37469F25DE1B4430BB7B95C8B0DF63A4.ashx. 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