{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:56:25Z","timestamp":1790711785241,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Perforations are a rare but serious complication of colorectal cancer. The current standard of treatment is emergent surgery followed by adjuvant chemotherapy. The concern with this approach is not only the uncertainty of achieving a R0 resection but also potential injury to adjacent vessels, nerves and ureters due to inflamed tissue planes. A subset of this patient population with a contained perforation who are clinically stable may have superior oncological outcomes with local sepsis control, neoadjuvant therapy followed by radical resection. The aim of this study is to report on the pre\u2010operative safety profile for neoadjuvant therapy in the setting of an abscess from colon cancer perforation and the short\u2010term oncological surgical quality outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective observational study, all consecutive perforated colon cancer receiving neoadjuvant therapy from Jan 2010 to Dec 2019 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 21 patients that met the inclusion criteria. The most common symptom at presentation was abdominal pain (71.4%) and most common site of perforation was sigmoid colon (61.9%). Local sepsis control was achieved with a combination of radiological or surgical drainage, diverting ostomy and\/or intravenous antibiotics. Thirteen patients had long\u2010course chemoradiation and eight patients had neoadjuvant chemotherapy. Of these, 13 (61.9%) had tumour regression, with one patient having a pathological complete response. All patients achieved a R0 resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a small subset of patients with colon cancer perforation, this study has demonstrated the potential safe usage of neoadjuvant therapy first before radical surgery to achieve a clear resection margin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15868","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T17:24:47Z","timestamp":1628702687000},"page":"3162-3172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is neoadjuvant therapy an alternative strategy to immediate surgery in locally perforated colon cancer?"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-2480","authenticated-orcid":false,"given":"Joseph C.","family":"Kong","sequence":"first","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Vic. Australia"},{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Colorectal Surgery Alfred Health Melbourne Vic. Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-8624","authenticated-orcid":false,"given":"Rathin","family":"Gosavi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Alfred Health Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Y.","family":"Ngan","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Vic. Australia"},{"name":"Division of Radiation Oncology Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Tillman","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Bednarski","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Heriot","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Vic. Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Vic. Australia"},{"name":"Division of Cancer Research Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-5361","authenticated-orcid":false,"given":"George J.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Warrier","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Vic. Australia"},{"name":"Department of Colorectal Surgery Alfred Health Melbourne Vic. Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Vic. Australia"},{"name":"Division of Cancer Research Peter MacCallum Cancer Centre Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318197e351"},{"issue":"13","key":"e_1_2_9_3_1","first-page":"36","article-title":"WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation","volume":"2018","author":"Pisano M","year":"2017","journal-title":"World J Emerg"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1674-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2336-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2473-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182567e13"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-017-0790-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481908500418"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.06.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004682"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.8.583"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049148"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70348-0"},{"key":"e_1_2_9_16_1","first-page":"1655","article-title":"Efficacy and safety of consolidation chemotherapy during the resting period in patients with local advanced rectal cancer","volume":"17","author":"Liang HQ","year":"2019","journal-title":"Oncol Lett"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:58:33Z","timestamp":1693209513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,28]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/codi.15868"],"URL":"https:\/\/doi.org\/10.1111\/codi.15868","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,28]]},"assertion":[{"value":"2021-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}