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This meta\u2010analysis aimed to identify the risk factors for metachronous PM after curative surgery for colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was registered at PROSPERO (CRD42020219187). Databases were searched for studies comparing clinical and histopathological characteristics between patients with metachronous peritoneal metastases from colorectal cancer (pmCRC) and patients without (non\u2010pmCRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six studies were included. Metachronous PM were positively associated with perforation (OR 1.920; 95% CI 1.144\u20133.223; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014), poor differentiation (OR 2.291; 1.603\u20133.275; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), T4 (OR 2.897; 1.248\u20136.726; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.013), N1\u20132 (OR 3.429; 2.684\u20134.381; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), mucinous adenocarcinoma (OR 4.175; 1.798\u20139.692; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), obstruction (OR 4.467; 1.919\u201310.398; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), synchronous ovarian metastases (OR 5.005; 1.140\u201321.977; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.033), positive peritoneal carcinoembryonic antigen mRNA (OR 9.472; 3.643\u201324.631; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), elevated serum carcinoembryonic antigen (preoperative group, OR 3.545, 1.486\u20138.459, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004; postoperative group, OR 13.673, 2.222\u201384.129, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), elevated serum cancer antigen 19\u20109 (preoperative group, OR 5.281, 2.146\u201312.994, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; postoperative group, OR 18.646, 6.429\u201354.083, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and positive peritoneal cytology (OR 25.884; 11.372\u201358.913; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These evidence\u2010based risk factors are conducive to designing early detection and proactive treatment strategies, enabling precision medicine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15880","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T19:02:58Z","timestamp":1629399778000},"page":"2846-2858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-7933","authenticated-orcid":false,"given":"Yuanxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiusen","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenle","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization: International Agency for Research on Cancer.GLOBOCAN 2020: Estimated cancer incidence mortality and prevalence worldwide in 2020. 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