{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:37:31Z","timestamp":1785325051153,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The use of standard CO<jats:sub>2<\/jats:sub> for insufflation during laparoscopic colorectal surgery may be associated with cooling and drying of the peritoneal cavity, contributing to perioperative hypothermia. The aim of this work was the assess the feasibility of a study to compare insufflation of warmed, humidified CO<jats:sub>2<\/jats:sub> (WHCO2) (using HumiGard, Fisher and Paykel Healthcare) with standard measures and its impact on the quality of recovery of surgical patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A single\u2010centre, triple\u2010blind, feasibility, randomized controlled trial (RCT) of adults scheduled for planned laparoscopic colorectal surgery. The primary outcome was recruitment. Secondary outcomes included feasibility of blinding, acceptability to patients and suitability of objective measures: patient\u2010reported quality of recovery using a validated questionnaire (QoR\u201040), patient pain scores and semi\u2010continuous core temperature measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine participants were randomized to either the WHCO2 group (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) or standard care alone (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). Recruitment to the study was successful and acceptable to patients. Blinding of the surgeons, patients and assessors was effective. Response rates to QoR\u201040 were high but ceiling effects were observed, indicating that the tool was unsuitable in this population. Fewer patients in the WHCO2 group reported postoperative nausea and vomiting (PONV) at days 1 (53% vs. 65%) and 3 (37% vs. 60%). The median hospital length of stay was 5.5\u00a0days in the standard care group and 4\u00a0days in the WHCO2 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A study of WHCO2 for insufflation in laparoscopic colorectal surgery would be highly acceptable to both patients and researchers. Potential reductions in PONV and hospital length of stay in patients treated with WHCO2 merit further investigation. The design of the full\u2010scale RCT will benefit from this feasibility study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15984","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T11:39:44Z","timestamp":1636371584000},"page":"3262-3271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Warmed and humidified insufflation to prevent perioperative hypothermia and improve the quality of recovery in elective laparoscopic colorectal resection patients: a feasibility study for a triple\u2010blind randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3493-7390","authenticated-orcid":false,"given":"Nicola","family":"Reeves","sequence":"first","affiliation":[{"name":"School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-3393","authenticated-orcid":false,"given":"Judith","family":"White","sequence":"additional","affiliation":[{"name":"Cedar, Cardiff and Vale University Health Board  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bird","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-9400","authenticated-orcid":false,"given":"Michael","family":"Shinkwin","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-4472","authenticated-orcid":false,"given":"Julie","family":"Cornish","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-0574","authenticated-orcid":false,"given":"Jared","family":"Torkington","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-4866-1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900914"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1139-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ases.12350"},{"issue":"0123456789","key":"e_1_2_13_7_1","article-title":"Influence of insufflated carbon dioxide on abdominal temperature compared to oesophageal temperature during laparoscopic surgery","author":"Groene P","year":"2020","journal-title":"Surg Endosc"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-201106001-00027"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.09.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013366"},{"key":"e_1_2_13_11_1","unstructured":"National Institute for Health and Care Excellence. NICE(2017).HumiGard for preventing inadvertent perioperative hypothermia. Available from:https:\/\/www.nice.org.uk\/guidance\/mtg31. Accessed 11 March 2021"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0391560319834837"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/lps.1991.1.127"},{"issue":"12","key":"e_1_2_13_14_1","first-page":"1","article-title":"Normothermic insufflation to prevent perioperative hypothermia and improve quality of recovery in elective colectomy patients: protocol for a randomized controlled trial","volume":"21","author":"Ryczek E","year":"2019","journal-title":"J Med Internet Res"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31817f6d76"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318296c732"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000551"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep370"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:58:31Z","timestamp":1693209511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/codi.15984"],"URL":"https:\/\/doi.org\/10.1111\/codi.15984","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"2021-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}