{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:55:15Z","timestamp":1747184115712,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>THD SphinKeeper\u00ae is an emerging surgical technique for faecal incontinence (FI). The safety, indications and efficacy of the procedure are still being investigated. The aim of this study is to present the first experience of SphinKeeper\u00ae in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective single\u2010centre observational study of patients undergoing SphinKeeper\u00ae implantation between February 2018 and September 2019. Baseline demographics, intraoperative and postoperative complications, Cleveland Clinic Faecal Incontinence Score, St Mark's Incontinence Score, Faecal Incontinence Quality of Life score (FIQOL), anorectal manometry and endo\u2010anal ultrasound were assessed preoperatively and 3 and 12\u00a0months after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients (2 male, 11 female) underwent implantation during the study period. Anal sphincter defects were present in 13 (76.9%) patients [external anal sphincter (EAS) defect, 2 <jats:bold>(<\/jats:bold>15.4%); internal anal sphincter (IAS) defect 4 (30.8%); EAS\u00a0+\u00a0IAS defect, 4 (30.8%)]. Median follow\u2010up was 32\u00a0months (range 18\u201337\u00a0months). There were four complications: one intraoperative (rectal perforation) and three postoperative (one implant extrusion, two implants that required removal due to malposition). At 12\u00a0months, an average of 9\/10 implants remained ideally placed in each patient. THD SphinKeeper\u00ae insertion was associated with an improvement in coping\/behaviour as measured using FIQOL (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047). However, the procedure did not improve FI scores or anorectal manometry parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, SphinKeeper\u00ae marginally improved symptoms of FI but there was no significant impact on anorectal manometric measurements. Larger\u2010scale studies are needed to determine the patient cohort most likely to benefit from this procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16037","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T08:09:17Z","timestamp":1640851757000},"page":"491-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A prospective trial of the THD SphinKeeper\u00ae for faecal incontinence"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-225X","authenticated-orcid":false,"given":"Rachel","family":"Colbran","sequence":"first","affiliation":[{"name":"Queen Elizabeth II Jubilee Hospital  Coopers Plains Qld Australia"},{"name":"Faculty of Medicine University of Queensland  St Lucia Qld Australia"},{"name":"Brisbane Academic Functional Colorectal Unit  Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Jubilee Hospital  Coopers Plains Qld Australia"},{"name":"Faculty of Medicine University of Queensland  St Lucia Qld Australia"},{"name":"Brisbane Academic Functional Colorectal Unit  Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-5638","authenticated-orcid":false,"given":"Andrea","family":"Warwick","sequence":"additional","affiliation":[{"name":"Queen Elizabeth II Jubilee Hospital  Coopers Plains Qld Australia"},{"name":"Faculty of Medicine University of Queensland  St Lucia Qld Australia"},{"name":"Brisbane Academic Functional Colorectal Unit  Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10298"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000797"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1396-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14801"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10050"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350620934932"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15277"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11558"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31822155e9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000709"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6382-y"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.16037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:06:11Z","timestamp":1692216371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/codi.16037"],"URL":"https:\/\/doi.org\/10.1111\/codi.16037","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"assertion":[{"value":"2021-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}