{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:49:04Z","timestamp":1792669744502,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Microscopically positive (R1) margins are associated with poorer outcomes in patients with colorectal cancer. However, the impact of subdivisions of R1 margins, be they to the primary tumour (R1 tumour) or to lymph node metastases (R1LNM), on patterns of relapse is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients treated for stage III colorectal cancer from 01 January 2016 to 31 December 2019 in four specialist centres were identified from the Danish national cancer registry. Patients were stratified into three groups according to margin status (R0 vs. R1 tumour vs. R1LNM). The primary outcomes were local recurrence\u2010free survival (LRFS), distant metastases\u2010free survival (DMFS) and disease\u2010specific survival (DSS).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1,164 patients were included, with R1 margins found in 237 (20.4%). Irrespective of tumour location, R1 tumour and R1LNM margins were independent prognostic factors for systemic relapse (R1 tumour HR 1.84, CI: 1.17\u20132.88,\n p<\/jats:italic>\n \u00a0=\u20090.008; R1LNM HR 1.59, CI: 1.12\u20132.27,\n p<\/jats:italic>\n \u00a0=\u20090.009) and disease\u2010related death (R1 tumour HR 2.08, CI: 1.12\u20133.85,\n p<\/jats:italic>\n \u00a0=\u20090.020; R1LNM HR 1.84, CI: 1.12\u20133.02,\n p<\/jats:italic>\n \u00a0=\u20090.016). Whereas R1 tumour margins were associated with poorer 3\u2010year LRFS in both colon and rectum cancer, R1LNM margins only reduced LRFS in patients with rectal cancer. Patterns of relapse differed between R1 subdivisions, with R1 tumour margins more likely to affect multiple anatomical sites, with a predilection for extra\u2010hepatic\/pulmonary metastases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Subdivisions of R1 margins have a distinct impact on the oncological outcomes and patterns of disease relapse in patients with stage III colorectal cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.16121","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T07:13:52Z","timestamp":1647674032000},"page":"828-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The impact of subdivisions of microscopically positive (\n R1<\/scp>\n ) margins on patterns of relapse in stage\n III<\/scp>\n colorectal cancer \u2013 A retrospective cohort study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4218-4648","authenticated-orcid":false,"given":"Henry G.","family":"Smith","sequence":"first","affiliation":[{"name":"Digestive Disease Center, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Skovgaards","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthi","family":"Chiranth","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rigshospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nis H.","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6739"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200203000-00009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.02024.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200204000-00001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.019802"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01365.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12960"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-019-01947-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25252"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24320"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15971"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15352"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.02.029"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713709"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6771"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.6297"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2974"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9030-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2011.110279"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.3616"}],"container-title":["Colorectal 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