{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:21:21Z","timestamp":1793215281024,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to investigate whether the application of nanofat containing stem cells improves continence in women who had previously undergone anal sphincteroplasty with unsatisfactory long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This prospective pilot study included nine women with various degrees of anal incontinence who had previously undergone anal sphincteroplasty due to obstetric trauma. In all patients, the Wexner Incontinence Score (\n                      <jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>\n                      ) and Faecal Incontinence Quality of Life Score (\n                      <jats:styled-content style=\"fixed-case\">FIQLS<\/jats:styled-content>\n                      ), as well as anal manometry and endoanal ultrasound measurements, were performed before the procedure and during follow\u2010up. In all patients, liposuction was performed and 50\u00a0\n                      <jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>\n                      of raw lipoaspirate was obtained and processed using a NanoFat Kit device. Approximately 20\u00a0\n                      <jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>\n                      of the mechanically emulsified and filtrated fat was obtained and the anal sphincter complex was infiltrated with it. Patient follow\u2010up was conducted in person or via telephone 6 and 12\u00a0months after the procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The squeeze pressure was significantly increased 6\u2009months after the procedure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.01). The external anal sphincter measured at the 12 o'clock position was significantly thicker (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.04). A significant decrease in the\n                      <jats:styled-content style=\"fixed-case\">WS<\/jats:styled-content>\n                      was observed both 6 and 12\u00a0months after the procedure compared with baseline values (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05 for both).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is the first to show that the application of nanofat as an injectable product improves continence in patients with unsatisfactory results after sphincteroplasty, suggesting it to be a promising and effective therapeutic tool. The procedure is safe and can be easily performed as an ambulatory procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.16148","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T06:58:28Z","timestamp":1650005908000},"page":"1054-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Application of nanofat for treatment of traumatic faecal incontinence after sphincteroplasty \u2013 A pilot study"],"prefix":"10.1111","volume":"24","author":[{"given":"Goran","family":"Barisic","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Clinic for Digestive Surgery \u2013 First Surgical Clinic, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Andjelkov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-0010","authenticated-orcid":false,"given":"Jovana","family":"Rosic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Miladinov","sequence":"additional","affiliation":[{"name":"Clinic for Digestive Surgery \u2013 First Surgical Clinic, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Kotur\u2010St\u0435vuljevic","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Dinic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelenko","family":"Jelenkovic","sequence":"additional","affiliation":[{"name":"COVID Hospital Batajnica, University Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Krivokapic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Clinic for Digestive Surgery \u2013 First Surgical Clinic, University Clinical Center of Serbia  Belgrade Serbia"},{"name":"Serbian Academy of Sciences and Arts  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Shackelford's Surgery of the Alimentary Tract","author":"Lee J","year":"2013"},{"key":"e_1_2_12_3_1","volume-title":"Epidemiology and Incidence of anal Incontinence: magnitude of the Problem. 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