{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:39:04Z","timestamp":1753439944493,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Locally advanced intestinal neoplasms including colon cancer may require radical <jats:italic>en bloc<\/jats:italic> pancreaticoduodenectomy and right hemicolectomy (PD\u2010RC) to achieve curative, margin\u2010negative resection, but the safety and benefit of this uncommon procedure has not been established. The Association of Coloproctology of Great Britain and Ireland IMPACT initiative has also highlighted a lack of awareness about current services available within the UK for patients with advanced colorectal cancer and concerns about low\u2010volume centres managing complex cases. Thus, we aimed to review the feasibility, safety and long\u2010term outcomes of this procedure at a single high\u2010volume hepatopancreaticobiliary surgery unit in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective cohort study was performed using a database of all consecutive patients with intestinal cancer who had been referred to our regional advanced multidisciplinary team and undergone PD\u2010RC in a 7\u2010year period (2013\u20132020). Clinico\u2010pathological and outcome data were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients (mean age 54\u2009\u00b1\u200913,\u00a08\/10 men) were identified. Final histology revealed the primary tumour sites were colon (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and duodenum (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). R0 resection was achieved in all cases. The major complication rate (Clavien\u2013Dindo\u2009\u2265\u20093) was 10% (1\/10) with no deaths within 90\u2009days of surgery. The Kaplan\u2013Meier estimated 5\u2010year overall survival was 83.3% (95% CI 58.3%\u2013100%). Univariate survival analysis identified perineural invasion and extra\u2010colonic origin as predictors of poor survival (log\u2010rank <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>En bloc<\/jats:italic> PD\u2010RC for locally advanced intestinal cancer can be performed safely with a high proportion of margin\u2010negative resections and resultant long\u2010term survival in carefully selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16303","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:41:00Z","timestamp":1660722060000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pancreaticoduodenectomy with right hemicolectomy for advanced malignancy: a single <scp>UK<\/scp> hepatopancreaticobiliary centre experience"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5982-0618","authenticated-orcid":false,"given":"Bibek","family":"Das","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-5150","authenticated-orcid":false,"given":"Matyas","family":"Fehervari","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Hamrang\u2010Yousefi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long R.","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhava","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Surgery St Mark's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan R. C.","family":"Spalding","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"},{"name":"Department of Hepatopancreaticobiliary Surgery Hammersmith Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-86"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586716"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.12.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.1205"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2376-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.01.515"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001437"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-015-2800-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001924"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.12.020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-021-00996-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200202000-00009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.04.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70348-0"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.06.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.02.001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.05.005"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481207800243"},{"issue":"5","key":"e_1_2_11_23_1","first-page":"587","article-title":"Resection for cure of carcinoma of the colon directly invading the duodenum or pancreatic head","volume":"179","author":"Curley SA","year":"1994","journal-title":"J Am Coll Surg"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.04.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.7.721"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000252402.33814.dd"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000720"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1345-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-021-00351-6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znab382"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0512"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr1062w"},{"issue":"9","key":"e_1_2_11_33_1","first-page":"917","article-title":"Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level","volume":"10","author":"Samowitz WS","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.235"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83391-x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-021-02426-7"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-017-1583-8"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30004-4"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-021-02471-2"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.16303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:46:06Z","timestamp":1692398766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/codi.16303"],"URL":"https:\/\/doi.org\/10.1111\/codi.16303","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"2022-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}