{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:31:05Z","timestamp":1778502665817,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A prolonged interval (&gt;4\u2009weeks) between short\u2010course radiotherapy (25\u2009Gy in five fractions) (SCRT\u2010delay) and total mesorectal excision for rectal cancer has been associated with a decreased postoperative complication rate and offers the possibility of organ preservation in the case of a complete tumour response. This prospective cohort study systematically evaluated patient\u2010reported bowel dysfunction and physician\u2010reported radiation\u2010induced toxicity for 8\u2009weeks following SCRT\u2010delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients who were referred for SCRT\u2010delay for intermediate risk, oligometastatic or locally advanced rectal cancer were included. Repeated measurements were done for patient\u2010reported bowel dysfunction (measured by the low anterior resection syndrome [LARS] questionnaire and categorized as no, minor or major LARS) and physician\u2010reported radiation\u2010induced toxicity (according to Common Terminology Criteria for Adverse Events version 4.0) before start of treatment (baseline), at completion of SCRT and 1, 2, 3, 4, 6 and 8\u2009weeks thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients were included; 31 (61%) were men and the median age was 67\u2009years (range 44\u201391). Patient\u2010reported bowel dysfunction and physician\u2010reported radiation\u2010induced toxicity peaked at weeks 1\u20132 after completion of SCRT and gradually declined thereafter. Major LARS was reported by 44 patients (92%) at some time during SCRT\u2010delay. Grade 3 radiation\u2010induced toxicity was reported in 17 patients (33%) and concerned predominantly diarrhoea. No Grade 4\u20135 radiation\u2010induced toxicity occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During SCRT\u2010delay, almost every patient experiences temporary mild\u2013moderate radiation\u2010induced toxicity and major LARS, but life\u2010threatening toxicity is rare. SCRT\u2010delay is a safe alternative to SCRT\u2010direct surgery that should be proposed when counselling rectal cancer patients on neoadjuvant strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16315","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T07:33:35Z","timestamp":1661758415000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patient\u2010 and physician\u2010reported radiation\u2010induced toxicity of short\u2010course radiotherapy with a prolonged interval to surgery for rectal cancer"],"prefix":"10.1111","volume":"25","author":[{"given":"Maaike E.","family":"Verweij","sequence":"first","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sieske","family":"Hoendervangers","sequence":"additional","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"},{"name":"Department of Surgery Jeroen Bosch Hospital  Den Bosch The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte M.","family":"von Hebel","sequence":"additional","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apollo","family":"Pronk","sequence":"additional","affiliation":[{"name":"Department of Surgery Diakonessenhuis  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anandi H. W.","family":"Schiphorst","sequence":"additional","affiliation":[{"name":"Department of Surgery Diakonessenhuis  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther C. J.","family":"Consten","sequence":"additional","affiliation":[{"name":"Department of Surgery Meander Medical Centre  Amersfoort The Netherlands"},{"name":"Department of Surgery University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke B.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Surgery St Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost T.","family":"Heikens","sequence":"additional","affiliation":[{"name":"Department of Surgery Rivierenland Hospital  Tiel The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel G. G.","family":"Verdaasdonk","sequence":"additional","affiliation":[{"name":"Department of Surgery Jeroen Bosch Hospital  Den Bosch The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Rozema","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Verbeeten Institute  Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena M.","family":"Verkooijen","sequence":"additional","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelmina M. U.","family":"van Grevenstein","sequence":"additional","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn P. W.","family":"Intven","sequence":"additional","affiliation":[{"name":"Division of Imaging and Oncology University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx224"},{"key":"e_1_2_13_3_1","unstructured":"National Institute for Health and Care Excellence.Colorectal Cancer NICE Guideline.2020.www.nice.org.uk\/guidance\/ng151. Accessed September 17 2022."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11220"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361402"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010580"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30086\u20104"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.03.016"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010017\u20105897\u20100"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30555\u20106"},{"key":"e_1_2_13_11_1","unstructured":"Primaire behandeling rectumcarcinoom \u2010 Richtlijn \u2010 Richtlijnendatabase.https:\/\/richtlijnendatabase.nl\/richtlijn\/colorectaal_carcinoom_crc\/primaire_behandeling_rectumcarcinoom_bij_crc.html. Published 2019. Accessed March 24 2022."},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1189094"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.07.017"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2020.09.024"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824f1c21"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31828fac0b"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14228"},{"key":"e_1_2_13_18_1","unstructured":"National Cancer InstituteCommon Terminology Criteria for Adverse Events (CTCAE) Version 4.0.2009.http:\/\/www.meddramsso.com. Accessed May 2 2022."},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201008060\u20104_12"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt124"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312695"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000258662"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800811143"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14790"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002750"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.222"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9223"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000862"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.01.005"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.12.441"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.16315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:46:31Z","timestamp":1692398791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/codi.16315"],"URL":"https:\/\/doi.org\/10.1111\/codi.16315","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,20]]},"assertion":[{"value":"2022-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}