{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:34:39Z","timestamp":1790303679480,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to explore potential associations between the body mass index (BMI) and the risk of colorectal cancer (CRC), including subsites of the colon, and cancer\u2010specific death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A registry\u2010based cohort study was conducted with baseline data gathered from the Norwegian Tuberculosis Screening Programme, collected between 1963 and 1975, and linked to follow\u2010up data from the Cancer Registry of Norway and the Norwegian Cause of Death Registry. Cox regression models were used to explore associations between BMI and CRC risk and cancer\u2010specific death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1\u00a0723\u2009692 included individuals, 76\u2009616 developed CRC during 55\u2009370\u2009707 person\u2010years of follow\u2010up. In men, a 5\u00a0kg\/m<jats:sup>2<\/jats:sup> increase in BMI was associated with an increased risk of colon cancer, including both right and left subsites, and rectal cancer. Allowing for nonlinearities, we found a U\u2010shaped association for the right colon and an inverse U\u2010shape for the left colon and rectum cancer. In women, a 5\u00a0kg\/m<jats:sup>2<\/jats:sup> increase in BMI in early adulthood was associated with increased risk of colon cancer, including both subsites. In women, an increased risk of CRC death with increasing BMI was found for colon cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Men of all ages have an increased risk of CRC with increasing BMI, with the highest risk for right\u2010sided colon cancer. An increased risk for colon cancer was also found in women with high BMI in early adulthood. Furthermore, women of all age groups appeared to have an increased risk of CRC death with higher BMI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16367","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:42:41Z","timestamp":1665574961000},"page":"375-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Risk and survival in colorectal cancer with increasing <scp>body mass index<\/scp>: A nationwide population\u2010based cohort study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-9748","authenticated-orcid":false,"given":"Usman","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Paediatric Surgery Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor \u00c5.","family":"Myklebust","sequence":"additional","affiliation":[{"name":"Department of Registration Cancer Registry of Norway  Oslo Norway"},{"name":"Department of Research and Innovation M\u00f8re and Romsdal Hospital Trust  \u00c5lesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trude E.","family":"Robsahm","sequence":"additional","affiliation":[{"name":"Department of Research Cancer Registry of Norway  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene F.","family":"Kielland","sequence":"additional","affiliation":[{"name":"Division for Molecular Nutrition Institute of Basic Medical Sciences, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Registration Cancer Registry of Norway  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn S.","family":"Sk\u00e5lhegg","sequence":"additional","affiliation":[{"name":"Division for Molecular Nutrition Institute of Basic Medical Sciences, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Mala","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Paediatric Surgery Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheraz","family":"Yaqub","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Paediatric Surgery Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health Organization.Obesity and overweight [Internet]. 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