{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:40Z","timestamp":1789000840112,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sclerotherapy with 3% polidocanol foam is becoming increasingly popular for the treatment of symptomatic I\u2013II or III degree haemorrhoidal disease (HD). However, there are no studies that have reported a follow\u2010up of more than 1\u2009year. The purpose of this study was to analyse the long\u2010term outcomes of sclerotherapy with 3% polidocanol foam in the treatment of II\u2013degree HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an open label, single\u2010arm, phase 2b trial conducted in 10 tertiary referral centres for HD. A total of 183 patients with II\u2013degree HD, aged between 18 and 75\u2009years with symptomatic HD according to the Goligher classification and unresponsive to medical treatment, were included in the study and underwent sclerotherapy with 3% polidocanol foam. The efficacy was evaluated in terms of bleeding score, haemorrhoidal disease symptom score (HDSS) and short health scale for HD (SHS\u2013HD) score. Successful treatment was defined as the complete absence of bleeding episodes after 7\u2009days (T1) according to the bleeding score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall success rate ranged from 95.6% (175\/183) at 1\u00a0year to 90.2% (165\/183) after the final 3\u00a0year follow\u2010up. The recurrence rate, based on the primary outcome, ranged from 12% (15\/125) to 28% (35\/125). The greatest increase in recurrence (15) was recorded between 12 and 18\u2009months of follow\u2010up, then another five between 18 and 24\u2009months. Both the HDSS and the SHS score remained statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001) from a median preoperative value of 11 (10\u201313) and 18 (15\u201320) to 0 (0\u20132) and 4 (0\u20134), respectively. Symptom\u2010free (HDSS\u00a0=\u00a00) patients, excluding patients converted to surgery, increased from 55.5% (101\/182) at 1\u00a0year to 65.1% at 3\u2009years (110\/169). There were no intraoperative complications in redo\u2010sclerotherapy nor additional adverse events (AEs) compared to the first 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sclerotherapy with 3% polidocanol foam is gradually establishing itself in the treatment of bleeding HD due to its repeatability, safety, convenience in terms of direct and indirect costs with the absence of discomfort for the patient as well as AEs rather than an excellent overall success rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.16380","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T05:18:54Z","timestamp":1666329534000},"page":"386-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sclerotherapy with 3% polidocanol foam to treat second\u2010degree haemorrhoidal disease: Three\u2010year follow\u2010up of a multicentre, single arm,\n                    <scp>IDEAL<\/scp>\n                    phase 2b trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-4671","authenticated-orcid":false,"given":"Gaetano","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Science University of Catanzaro  Catanzaro Italy"},{"name":"Minerva Surgical Service  Catanzaro Italy"},{"name":"Department of Surgical Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-1111","authenticated-orcid":false,"given":"Arcangelo","family":"Picciariello","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ transplantation and Inter\u2010Department Research Centre for Pelvic Floor Disease (CIRPAP) University Aldo Moro of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-1050","authenticated-orcid":false,"given":"Renato","family":"Pietroletti","sequence":"additional","affiliation":[{"name":"Proctology Unit, Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Novelli","sequence":"additional","affiliation":[{"name":"Biostat Research S.A.S  Borgomanero Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0933","authenticated-orcid":false,"given":"Alessandro","family":"Sturiale","sequence":"additional","affiliation":[{"name":"Proctology and Pelvic Floor Clinical Centre Cisanello University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-4689","authenticated-orcid":false,"given":"Roberta","family":"Tutino","sequence":"additional","affiliation":[{"name":"Chirurgia 1, Azienda ULSS 2 Marca Trevigiana Ospedale Regionale Treviso  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Laforgia","sequence":"additional","affiliation":[{"name":"Surgical Unit \"M. Rubino\" Department of Emergency and Organ Transplantation University Aldo Moro of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Moggia","sequence":"additional","affiliation":[{"name":"Department of General Surgery Infermi Hospital, Rivoli  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pozzo","sequence":"additional","affiliation":[{"name":"Department of General Surgery \"Degli Infermi\" Hospital  Biella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Roveroni","sequence":"additional","affiliation":[{"name":"Department of Surgery Aosta Hospital  Aosta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bianco","sequence":"additional","affiliation":[{"name":"General Surgery Unit Cetraro Hospital  Cetraro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Realis Luc","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery S. Rita Clinic  Vercelli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giuliani","sequence":"additional","affiliation":[{"name":"General Surgery Unit, San Salvatore Hospital, Department of Biotechnological and Applied Clinical Sciences University of L'Aquila  L'Aquila Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Diaco","sequence":"additional","affiliation":[{"name":"Minerva Surgical Service  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-1377","authenticated-orcid":false,"given":"Gabriele","family":"Naldini","sequence":"additional","affiliation":[{"name":"Proctology and Pelvic Floor Clinical Centre Cisanello University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-4692","authenticated-orcid":false,"given":"Mario","family":"Trompetto","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery S. Rita Clinic  Vercelli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Perinotti","sequence":"additional","affiliation":[{"name":"Department of General Surgery \"Degli Infermi\" Hospital  Biella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-2530","authenticated-orcid":false,"given":"Vito","family":"D'Andrea","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3368-4715","authenticated-orcid":false,"given":"Pierluigi","family":"Lobascio","sequence":"additional","affiliation":[{"name":"Surgical Unit \"M. 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