{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:33:58Z","timestamp":1764333238911,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We look at the effect of introducing the faecal immunochemical test (FIT) in the straight\u2010to\u2010test 2\u2010week pathway for change in bowel habit (CIBH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The FIT in primary care triages 2\u2010week wait (2WW) colorectal referrals for patients aged 60\u2009years and above for straight\u2010to\u2010test CT colonography (CTC). We compare the impact of the FIT on numbers of 2WW CTCs, in the year before and after FIT, in both colorectal cancer (CRC) detection and cost\u2010effectiveness at both 4\u2009\u03bcg Hb\/g faeces and 10\u2009\u03bcg Hb\/g faeces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a threshold of 4\u00a0\u03bcg Hb\/g faeces, the positive predictive value of the FIT for diagnosis of CRC is 5.0% with a negative predictive value of 99.8% and a polyp detection rate of 25.5%. The introduction of the FIT resulted in a reduction in the number of CTCs performed through the CIBH pathway from a mean of 143.9 per month prior to the FIT to 66.8 CTCs per month once the FIT was well established. Given a FIT threshold of 10\u00a0\u03bcg Hb\/g the number of CTCs would be predicted to fall by 70.4% to 42.6 CTCs per month resulting in higher CRC and polyp detection rate, and an estimated annual cost saving of \u00a3238\u2009258 in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FIT use in primary care improves the yield of 2WW referrals for CIBH alone and reduces the burden and cost of investigations to exclude CRC. Improvements may be possible by increasing the cut\u2010off employed, without adversely affecting the risk of missing a cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16445","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T20:53:10Z","timestamp":1670446390000},"page":"640-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Faecal immunochemical testing reduces demand and improves yield of Leicester's 2\u2010week pathway for change in bowel habit"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-3171","authenticated-orcid":false,"given":"Farah","family":"Khasawneh","sequence":"first","affiliation":[{"name":"University Hospitals of Leicester NHS Trust, University of Leicester  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Osborne","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Danaher","sequence":"additional","affiliation":[{"name":"GP Principal at Groby Road Medical Centre  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Barnes","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline J.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals, NHS Trust University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baljit","family":"Singh","sequence":"additional","affiliation":[{"name":"University Hospitals of Leicester NHS Trust  Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Research UK. [cited 2022 Jan 5]. Available from:https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/bowel\u2010cancer\/incidence"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp10X483175"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.05.046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp09X420860"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2014.8.2.117"},{"key":"e_1_2_8_7_1","unstructured":"Quantitative faecal immunochemical tests to guide referral for colorectal cancer in primary care diagnostics guidance;2017. 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