{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:52:17Z","timestamp":1788573137058,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the diagnostic value of apparent diffusion coefficient (ADC) on 3\u00a0T device for the prediction of tumoral response to neoadjuvant chemoradiotherapy (nCRT) and for the response assessment after nCRT in patients with locally advanced rectal cancer (LARC), using pathology as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients affected by LARC undergoing 3.0\u00a0T MRI before and after nCRT were retrospectively selected. After the conventional acquisition of high resolution T2\u2010weighted sequences, diffusion\u2010weighted MRI (DW\u2010MRI) was performed using a spin\u2010echo echo\u2010planar sequence with multiple <jats:italic>b<\/jats:italic> values (150, 500, 1000, 1500\u2009s\/mm<jats:sup>2<\/jats:sup>). Fitted ADC values were calculated for each rectal lesion before and after nCRT by drawing a hand\u2010made region of interest (ROI) around the tumour outline. All patients underwent surgery and pathological staging (classified according to tumour regression grading [TRG] and to tumour and node [TN]) represented the reference standard. Pretreatment ADC value (pre\u2010ADC), ADC value obtained after nCRT (post\u2010ADC) and the difference between post\u2010ADC and pre\u2010ADC (\u0394ADC) were correlated with both the TRG classes and the TN staging system in each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ADC values obtained in the post nCRT examination and the \u0394ADC were statistically related both to TRG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0004; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0126, respectively) and TN (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0484; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0673, respectively) stages at histopathology. On the contrary, the pre\u2010ADC was not related either to the TRG classes or to the lesion TN staging system (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>3\u2009T DW\u2010MRI using ADC value can be useful to assess the efficacy of nCRT in LARC; in fact, post\u2010ADC and \u0394ADC values improve MR capability to evaluate tumour response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16483","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T18:55:37Z","timestamp":1673636137000},"page":"905-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Response assessment of locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Is apparent diffusion coefficient useful on <scp>3\u00a0T<\/scp> magnetic resonance 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Interventional Radiology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cacciato\u2010Insilla","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Campani","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Caramella","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Radiology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"546","article-title":"Neoadjuvant 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