{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:51:32Z","timestamp":1770972692895,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Appendiceal neoplasms are rare subtypes of colorectal tumours that mainly affect younger patients some 20\u2009years earlier than other colon tumours. The aim of this study was to gain more insight into the histological subtypes of this rare disease and include cases previously excluded, such as mucinous neoplasia.<\/jats:p><\/jats:sec>Method<\/jats:title>The cohort study included 1097 patients from the Munich Cancer Registry (MCR) diagnosed between 1998 and 2020. Joinpoint analysis was used to determine trend in incidence. Baseline demographic comparisons and survival analyses using competing risk and univariate\/multivariate methods were conducted according to tumour histology: adenocarcinoma (ADENO), neuroendocrine neoplasia (NEN), mixed adeno\u2010neuroendocrine carcinoma (MANEC), and low\u2010 (LAMN) and high\u2010grade mucinous neoplasia (HAMN).<\/jats:p><\/jats:sec>Results<\/jats:title>Up to 2016 the number of cases increased significantly [annual per cent change (APC)\u00a0=\u00a06.86, p<\/jats:italic>\u00a0<\u20090.001] followed by a decline in the following years (APC\u00a0=\u00a0\u221214.82, p<\/jats:italic>\u00a0=\u20090.014; average APC\u00a0=\u00a02.5, p<\/jats:italic>\u00a0=\u20090.046). Comparison of all patients showed that NEN (48.4%) and mucinous neoplasms (11.6%) had a considerably better prognosis than ADENO (36.0%) and MANEC (3.0%, p<\/jats:italic>\u00a0<\u20090.0001). A multivariate analysis within the NEN and ADENO subgroups revealed that further histological classification was not prognostically relevant, while older age and regional tumour spread at diagnosis were associated with a poor prognosis. ADENO histology with high tumour grade and appendectomy only was also associated with poorer survival.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Appendiceal neoplasms are histologically heterogeneous; however, this diversity becomes less relevant compared with the marked difference from cancers of the remaining colon. The previously observed increase in cases appears to be abating; fewer cases of appendicitis and\/or appendectomies or changes in histopathological assessment may be behind this trend.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16510","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T09:48:23Z","timestamp":1675763303000},"page":"943-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The other colon cancer: a population\u2010based cohort study of appendix tumour trends and prognosis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-8959","authenticated-orcid":false,"given":"Kathrin","family":"Halfter","sequence":"first","affiliation":[{"name":"Munich Cancer Registry (MCR) at the Institute of Medical Information Processing, Biometry and Epidemiology (IBE) Ludwig\u2010Maximilians\u2010University (LMU) Munich 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Internal Medicine II, University Hospital Ludwig\u2010Maximilians\u2010University (LMU) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilko","family":"Weichert","sequence":"additional","affiliation":[{"name":"Institute of Pathology Technical University Munich (TUM) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Friess","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Klinikum rechts der Isar Technical University Munich (TUM) School of Medicine Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Technical University Munich (TUM) Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Kremer","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Clinic Munich\u2010Neuperlach Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Ruppert","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinic Munich\u2010Neuperlach Hospital Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Hoelzl","sequence":"additional","affiliation":[{"name":"Office of Pathology Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Krenz","sequence":"additional","affiliation":[{"name":"Department of General, Vascular, Thyroid and Thorax Surgery, Hospital Dritter Orden Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Nerlich","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Clinic Munich\u2010Bogenhausen Munich 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