{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:41:35Z","timestamp":1783942895432,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Monkeypox virus (MPXV) has been spreading in many European countries, the USA and Canada since May 2022. General symptoms, skin and anoperineal lesions have been reported. Anal pain is often reported, but anal canal lesions have yet to be described in these patients. The aim of this study was to describe anoperineal lesions in patients infected with MPXV undergoing systematic margin and anal canal examination at a tertiary care centre in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this prospective descriptive study, systematic anal examination was performed in 20 patients diagnosed with MPXV infection at Bichat Hospital, Paris, France between 6 and 11 July 2022. Anal swabs were also obtained from all these patients for polymerase chain reaction testing for MPXV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the patients were men that have sex with men (MSM). Sixteen patients had anal symptoms: 13 reported anal pain, and the other anal symptoms described were anal bleeding (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), pruritus (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), dyschezia (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), tenesmus (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), burning (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), swelling (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) and discharge of mucus (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). Proctological examination detected: (i) anal margin lesions in 14 patients (vesicles, <jats:italic>n<\/jats:italic>\u00a0=\u00a08; pustules, <jats:italic>n<\/jats:italic>\u00a0=\u00a06; ulceration, <jats:italic>n<\/jats:italic>\u00a0=\u00a06); (ii) anal canal lesions in 16 patients (ulceration, <jats:italic>n<\/jats:italic>\u00a0=\u00a013; ulcers, <jats:italic>n<\/jats:italic>\u00a0=\u00a04; pustules, <jats:italic>n<\/jats:italic>\u00a0=\u00a01), seven of whom presented anal hypertonia; and (iii) rectal lesions in 12 patients (congested rectum, <jats:italic>n<\/jats:italic>\u00a0=\u00a06; erythema, <jats:italic>n<\/jats:italic>\u00a0=\u00a010; ulcers, <jats:italic>n<\/jats:italic>\u00a0=\u00a02; not seen in one case). the presence of mucus was noted in 10 patients and the presence of blood in six patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to describe anal canal lesions in patients infected with MPXV. Most of the observed lesions were ulceration, accounting for the pain reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16513","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T08:11:21Z","timestamp":1675930281000},"page":"1002-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anogenital symptoms and lesions in a series of 20 patients infected with monkeypox virus"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-7446","authenticated-orcid":false,"given":"Samia","family":"Rekik","sequence":"first","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Proctologie AP\u2010HP, H\u00f4pital Bichat Claude\u2010Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane Le","family":"Pluart","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, AP\u2010HP H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Service de Virologie, Universit\u00e9 Paris Cit\u00e9 INSERM, IAME, UMR 1137, AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Service de Virologie, Universit\u00e9 Paris Cit\u00e9 INSERM, IAME, UMR 1137, AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-7953","authenticated-orcid":false,"given":"Anne","family":"Laurain","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Proctologie AP\u2010HP, H\u00f4pital Bichat Claude\u2010Bernard  Paris France"},{"name":"Clinique Blomet Ramsay G\u00e9n\u00e9rale de Sant\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, AP\u2010HP H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abramowitz","sequence":"additional","affiliation":[{"name":"Service de Gastro\u2010ent\u00e9rologie et Proctologie AP\u2010HP, H\u00f4pital Bichat Claude\u2010Bernard  Paris France"},{"name":"Clinique Blomet Ramsay G\u00e9n\u00e9rale de Sant\u00e9  Paris France"},{"name":"Hepato\u2010gastro\u2010enterology Department Bichat Claude Bernard University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2019.03.001"},{"key":"e_1_2_10_3_1","unstructured":"WHO.Multi\u2010country monkeypox outbreak: situation update. June 10 2022.https:\/\/www.who.int\/emergencies\/disease\u2010outbreaknews\/item\/2022\u2010DON392https:\/\/www.who.int\/emergencies\/disease\u2010outbreak\u2010news\/item\/2022\u2010DON396(accessed June 11 2022)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00411\u2010X"},{"key":"e_1_2_10_5_1","article-title":"Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review","volume":"12","author":"Bragazzi NL","year":"2022","journal-title":"J Med Virol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa143"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01436-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-072410","article-title":"Clinical features and novel presentations of human monkeypox in a Central London centre during the 2022 outbreak: descriptive case series","volume":"378","author":"Patel A","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010022\u201001896\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"BaetselierID DijckCV KenyonC CoppensJ BosscheDV den SmetH et al.Asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium2022[cit\u00e9 26 ao\u00fbt 2022]. p. 2022.07.04.22277226.","DOI":"10.1101\/2022.07.04.22277226"},{"key":"e_1_2_10_11_1","unstructured":"Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie.Gestion des pr\u00e9l\u00e8vements biologiques d'un patient suspect ou confirm\u00e9 d'infection par le monkeypox virus (MPXV) Version 1 _ MAJ: 11\/06\/2022.https:\/\/www.sfm\u2010microbiologie.org\/wp\u2010content\/uploads\/2022\/09\/Recommandations\u2010SFM\u2010_\u2010MPXV_V2def2_\u201016092022.pdf"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.16513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:14:55Z","timestamp":1692443695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/codi.16513"],"URL":"https:\/\/doi.org\/10.1111\/codi.16513","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]},"assertion":[{"value":"2022-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}