{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:58:20Z","timestamp":1790855900695,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare transanal irrigation with conservative bowel management for the treatment of bowel dysfunction in Spina bifida (SB) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SB and bowel dysfunction were randomly assigned to receive either transanal irrigation or conservative bowel management. The effectiveness of the treatment was defined as a decrease of 4 points in the neurogenic bowel dysfunction (NBD) score at week 10. Data on incontinence (Cleveland scores; Jorge\u2010Wexner [JW]) and constipation (Knowles\u2010Eccersley\u2010Scott Symptom Constipation Score [KESS]) were recorded at 10 and 24\u2009weeks after inclusion. Data were analysed on an intention\u2010to\u2010treat basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 patients were randomised: 16 patients to conservative bowel management and 18 patients to transanal irrigation. A total of 19\/31 (61%) patients improved at week 10, 13 (76%) in the transanal irrigation group versus six (43%) in the conservative group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.056). In the irrigation group, the decrease in NBD score was \u22126.9 (\u22129.9 to \u22124.02) versus \u22121.9 (\u22126.5 to \u22122.8) in the conservative group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049 in univariate and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004 in multivariate analysis). The NBD, Cleveland (JW and KESS) and Rosenberg scores were significantly lower in the transanal irrigation group than in the conservative bowel management group at week 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This prospective, randomised, controlled, multicentre study in adult patients with SB suggests that transanal irrigation may be more effective than conservative bowel management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16518","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T11:18:53Z","timestamp":1676632733000},"page":"1267-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transanal irrigation is a better choice for bowel dysfunction in adults with Spina bifida: A randomised controlled trial"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"Charl\u00e8ne","family":"Brochard","sequence":"first","affiliation":[{"name":"Service d'Explorations Fonctionnelles Digestives CHRU Pontchaillou  Rennes France"},{"name":"The Enteric Nervous System in Gut and Brain Disorders INSERM, TENS Universit\u00e9 de Nantes  Nantes France"},{"name":"Centre R\u00e9f\u00e9rence Maladies Rares Spina Bifida CHRU Pontchaillou  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Jezequel","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rence Maladies Rares Spina Bifida CHRU Pontchaillou  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Blanchard\u2010Dauphin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Physique et R\u00e9adaptation H\u00f4pital Swynghedauw  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Kerdraon","sequence":"additional","affiliation":[{"name":"Centre Mutualiste de Kerpape  Ploemeur France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Perrouin\u2010Verbe","sequence":"additional","affiliation":[{"name":"The Enteric Nervous System in Gut and Brain Disorders INSERM, TENS Universit\u00e9 de Nantes  Nantes France"},{"name":"Service universitaire de M\u00e9decine Physique et R\u00e9adaptation Neurologique Nantes Universit\u00e9  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Leroi","sequence":"additional","affiliation":[{"name":"Service d'Explorations Fonctionnelles CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Reymann","sequence":"additional","affiliation":[{"name":"INSERM CIC 1414, INPHY, Universit\u00e9 de Rennes 1  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Peyronnet","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rence Maladies Rares Spina Bifida CHRU Pontchaillou  Rennes France"},{"name":"INSERM CIC 1414, INPHY, Universit\u00e9 de Rennes 1  Rennes France"},{"name":"Service d'Urologie CHRU Pontchaillou  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Mor\u00e7et","sequence":"additional","affiliation":[{"name":"INSERM CIC 1414, INPHY, Universit\u00e9 de Rennes 1  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rence Maladies Rares Spina Bifida CHRU Pontchaillou  Rennes France"},{"name":"INSERM CIC 1414, INPHY, Universit\u00e9 de Rennes 1  Rennes France"},{"name":"Service des Maladies de l'Appareil Digestif CHRU Pontchaillou, Universit\u00e9 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