{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:03:47Z","timestamp":1788379427401,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Follow\u2010up after colorectal cancer requires frequent surveillance of the tumour marker carcinoembryonic antigen (CEA). Home\u2010based blood sampling could be beneficial in terms of patients' well\u2010being and societal cost\u2010effectiveness. Blood sampling by venepuncture is unsuitable for home\u2010based sampling. The aim of this feasibility study is to evaluate the long\u2010term whole\u2010blood stability of CEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this prospective feasibility study capillary blood withdrawal was collected in a Hem\u2010Col<jats:sup>\u00ae<\/jats:sup> microtube containing a patented stabilization buffer using an internal lithium standard to correct for dilution. Long\u2010term whole\u2010blood stability was considered adequate if the relative bias in CEA concentration between delayed analysis of capillary samples and directly processed venepuncture is within the total error margin of CEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty two colorectal cancer patients were included to determine the stability of CEA in capillary sampling compared with directly processed (i.e. within 2\u00a0h) venepuncture sampling. The median time between venous sampling and CEA analysis and capillary sampling and CEA analysis was 2\u00a0h (interquartile range 1\u20134\u00a0h) and 76\u2009h (interquartile range 74\u201395\u2009h), respectively. A Bland\u2013Altman difference plot excluding outliers showed an overall relative bias of \u22121.23%. The two capillary samples in our outlier analysis also showed the highest lithium concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Home\u2010based capillary sampling with the use of the Hem\u2010Col<jats:sup>\u00ae<\/jats:sup> buffer is a feasible method for CEA determination when analysed within 4\u2009days after blood withdrawal, allowing monitoring for colorectal cancer patients from home. High lithium concentrations due to insufficient filling of the Hem\u2010Col<jats:sup>\u00ae<\/jats:sup> tube suggest less reliable CEA measurements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16536","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T04:30:14Z","timestamp":1679459414000},"page":"1163-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reliable capillary sampling of carcinoembryonic antigen at home: the CASA feasibility study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-9409","authenticated-orcid":false,"given":"Kelly R.","family":"Voigt","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"Wullaert","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC Cancer Institute  Rotterdam The Netherlands"},{"name":"Department of Clinical Chemistry Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"IKNL.Darmkanker: IKNL. 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