{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:22Z","timestamp":1787014042293,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Perianal Paget's disease (PAPD) is a rare disorder with a predisposition to anal and colorectal malignancies and an unclear prognosis. Our previous 25\u2010year series demonstrated a non\u2010aggressive nature. This study aims to describe our updated institutional experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective review of all patients diagnosed with primary PAPD from 1991 to 2021. A prospectively maintained institutional database was searched which included demographics, clinical and pathological manifestations, treatment methods, recurrence, oncological outcome and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty patients were diagnosed with PAPD. Fifteen were women (50%); the average age at diagnosis was 71\u2009\u00b1\u200910.7\u2009years, and the average lesion size was 3.7\u2009\u00b1\u20092.6\u2009cm. At diagnosis, 12 (40%) were harbouring invasive anal adenocarcinoma. Eight (27%) developed adenocarcinomas concurrent with PAPD recurrence at a mean interval of 9\u2009\u00b1\u20094.4\u2009years (range 1.9\u201314.8). The Kaplan\u2013Meier curve estimated overall survival of 93%, 86%, 82%, 65% and 56% at 1, 3, 5, 10 and 15\u2009years, respectively. Median survival was 16\u2009years. Six (20%) had disease\u2010related mortality. Initially, nine (30%) were treated with abdominoperineal resection (APR), 15 (50%) underwent local resection, three (10%) were treated with radiotherapy, two (7%) received only topical therapy and one (3%) chose observation. Fifteen (50%) experienced recurrence of PAPD, two after undergoing APR. Five (17%) had persistent disease until death. Only 10 (33%) did not experience PAPD recurrence, seven of whom underwent APR. The mean follow\u2010up time was 9.2\u2009\u00b1\u20096.2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perianal Paget's disease is an aggressive entity with high rates of synchronous anal adenocarcinoma at diagnosis and development of metachronous adenocarcinoma later in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.16549","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:54:43Z","timestamp":1679446483000},"page":"1213-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Perianal Paget's\u2014an aggressive disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-0017","authenticated-orcid":false,"given":"Yaron","family":"Rudnicki","sequence":"first","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahael M.","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Batra","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie L.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery Mayo 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