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Weight loss may improve morbidity, but it is uncertain whether patients can follow an intensive weight loss intervention while waiting for surgery and there are concerns about muscle mass loss. The aim of this trial is to assess the feasibility of intentional weight loss in this setting and determine progression to a definitive trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CARE is a prospectively registered, multicentre, feasibility, parallel, randomised controlled trial with embedded evaluation and optimisation of the recruitment process. Participants with excess weight awaiting curative colorectal resection for cancer are randomised 1:1 to care as usual or a low\u2010energy nutritionally\u2010replete total diet replacement programme with weekly remote behavioural support by a dietitian. Progression criteria will be based on the recruitment, engagement, adherence, and retention rates. Data will be collected on the 30\u2010day postoperative morbidity, the typical primary outcome of prehabilitation trials. Secondary outcomes will include, among others, length of hospital stay, health\u2010related quality of life, and body composition. Qualitative interviews will be used to understand patients' experiences of and attitudes towards trial participation and intervention engagement and adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CARE will evaluate the feasibility of intensive intentional weight loss as prehabilitation before colorectal cancer surgery. The results will determine the planning of a definitive trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16687","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T04:40:39Z","timestamp":1690864839000},"page":"1910-1920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>CARE<\/scp>: Protocol of a randomised trial evaluating the feasibility of preoperative intentional weight loss to support postoperative recovery in patients with excess weight and colorectal cancer"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1955-7234","authenticated-orcid":false,"given":"Dimitrios A.","family":"Koutoukidis","sequence":"first","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-2920","authenticated-orcid":false,"given":"Susan A.","family":"Jebb","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4703-8378","authenticated-orcid":false,"given":"Claire","family":"Foster","sequence":"additional","affiliation":[{"name":"Centre for Psychosocial Research in Cancer: CentRIC+ in Health Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Wheatstone","sequence":"additional","affiliation":[{"name":"Patient and Public Involvement Representative  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Horne","sequence":"additional","affiliation":[{"name":"Surgical Intervention Trials Unit, Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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