{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:12:19Z","timestamp":1791403939621,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Locally advanced and recurrent colorectal cancer can require extended surgery, including reconstruction of the vagina. This complex surgery carries high morbidity. The aim of this study was to analyse the impact on female sexual functioning of pelvic exenteration (PE), with or without vaginal flap reconstruction, for locally advanced or recurrent colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The protocol with search strategies for PubMed (Medline), EMBASE and the Cochrane Library was registered in PROSPERO. Studies published from 2000 onwards meeting the inclusion criteria were considered. Study selection (Rayyan), data extraction, rating of evidence (GRADE) and risk of bias (ROBINS\u2010I) were conducted independently by two reviewers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of 2479 identified records were included: four retrospective and two cross\u2010sectional studies. Of all 860 patients included, PE was performed in 314 patients. Seven hundred and thirty\u2010two had rectal cancer (85.1%), 80 nonadvanced rectal cancer (10.9%), 393 locally advanced rectal cancer (53.7%) and 217 locally recurrent rectal cancer (29.6%); for 45 patients the type of rectal cancer remained unspecified (6.1%). Three studies reported on both preoperative and postoperative female sexual activity. Of the 153 women who were sexually active preoperatively, 64 (41.8%) reported postoperative sexual activity. The VRAM flap was used the most frequently and resulted in a sexual activity ratio of 18% postoperatively. Four studies, using six different validated questionnaires, reported mostly lowered sexual functioning postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most studies showed that PE can result in severe sexual dysfunction despite reconstruction. Future prospective studies can fill the current knowledge gap by assessing long\u2010term sexual outcomes in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16767","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:22:16Z","timestamp":1698124936000},"page":"2294-2305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A systematic review of female sexual function after surgery for locally advanced or recurrent colorectal cancer \u2013 first step to filling the knowledge gap"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6630-4072","authenticated-orcid":false,"given":"Elke","family":"Platteau","sequence":"first","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Ghent Belgium"},{"name":"Department of Gastrointestinal Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-1080","authenticated-orcid":false,"given":"Andreas","family":"Denys","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Ghent Belgium"},{"name":"Department of Gastrointestinal Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-7847","authenticated-orcid":false,"given":"Marlon","family":"Buncamper","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Ghent Belgium"},{"name":"Department of Plastic Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-582X","authenticated-orcid":false,"given":"Gabrielle H.","family":"van Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Human Structure and Repair Ghent University  Ghent Belgium"},{"name":"Department of Gastrointestinal Surgery Ghent University Hospital  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984870"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194807)1:2<177::AID-CNCR2820010203>3.0.CO;2-A"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70204-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17734"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-03893-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390350043009"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.11.044"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000797964.31949.b4"},{"key":"e_1_2_12_11_1","article-title":"Complications and impact on quality of life of vertical rectus abdominis myocutaneous (VRAM) flaps for reconstruction in pelvic exenteration surgery","volume":"20","author":"Van Ramshorst G","year":"2018","journal-title":"Colorectal Dis"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000154158.41973.a2"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001632"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30077"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182a97ea2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.20663"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102-672020190001e1507"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000008"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.29252\/wjps.10.1.114"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007976"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15718"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14523"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15956"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.06.010"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4806.19.06080-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1005-9_668"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000096451.86834.e5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02668.x"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2019.04.001"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.12.1340"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181fed5f3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14925"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31827a267c"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28430"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31826e4bd5"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02894.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.030"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.256"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900296"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr133"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00719"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.537"},{"issue":"1","key":"e_1_2_12_46_1","first-page":"49","article-title":"Sex inequalities in medical research: a systematic scoping review of the literature","volume":"3","author":"Merone L","year":"2022","journal-title":"Womens Health Rep."},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2032-z"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1947"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0867-9"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.16767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T08:35:22Z","timestamp":1704616522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.16767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/codi.16767"],"URL":"https:\/\/doi.org\/10.1111\/codi.16767","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]},"assertion":[{"value":"2023-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}