{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:53:45Z","timestamp":1783511625229,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The primary therapeutic option for anal cancer treatment is chemoradiotherapy resulting in 80% survival. The aim of this study was to assess long\u2010term bowel function impairment and anal pain at 3 and 6\u2009years after anal cancer diagnosis, based on a hypothesis of an increase in impairment over time. A secondary aim was to investigate if chemoradiotherapy increased the risk for bowel impairment, compared to radiotherapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The ANal CAncer study (ANCA) consists of a national Swedish cohort of patients diagnosed with anal cancer between 2011\u20132013. Patients within the study were invited to respond to a study\u2010specific questionnaire at 3\u2010 and 6\u2010years after diagnosis. Descriptive analyses for the primary endpoint and ordinal logistic regressions for secondary endpoint were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 388 patients (84%) were included in the study. At 3\u2009years of follow\u2010up, 264 patients were alive. A total of 195 of these patients (74%) answered a study specific questionnaire, and at 6\u2009years 154 patients (67%). Fifty\u2010seven percent experienced bowel urgency at both 3 and 6\u2009years. There was an increased risk for repeated bowel movement within 1 h (OR 2.44 [95% CI: 1.08\u20135.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.03]) at 3\u2009years in patients who had been treated by chemoradiation compared to radiotherapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Impairment in bowel function and anal pain after anal cancer treatment should be expected and remains after 6\u2009years. This suggests that long\u2010term follow\u2010up may be necessary in some form after customary follow\u2010up. The addition of chemotherapy increases long\u2010term side effects of bowel function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16814","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:38:10Z","timestamp":1701131890000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient reported long\u2010term side effects on bowel function and anal pain in anal cancer survivors \u2013 3\u2010 and 6\u2010year results from the Swedish national ANCA study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-4885","authenticated-orcid":false,"given":"Anna","family":"Axelsson","sequence":"first","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Oncology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital\/Sahlgrenska  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Oncology Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital\/Sahlgrenska  Gothenburg Sweden"},{"name":"Department of Oncology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-5605","authenticated-orcid":false,"given":"Eva","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital\/\u00d6stra  Gothenburg 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-4904","authenticated-orcid":false,"given":"Eva","family":"Angenete","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital\/\u00d6stra  Gothenburg 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