{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:59:13Z","timestamp":1778327953601,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The gastrointestinal bile acid (BA)\/microbiota axis has emerged as a potential mediator of health and disease, particularly in relation to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer. Whilst it presents an exciting new avenue for therapies, it has not yet been characterized in surgical resection of the ileum, where BA reabsorption occurs. The identification of BA\/microbiota signatures may provide future therapies with perioperative personalized medicine. In this work we conduct a systematic review with the aim of investigating the microbiome and BA changes that are associated with resection of the ileum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The databases included were MEDLINE, EMBASE, Web of Science and Cochrane libraries. The outcomes of interest were faecal microbiome and BA signatures after ileal resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the initial 3106 articles, three studies met the inclusion\/exclusion criteria for data extraction. A total of 257 patients (46% surgery, 54% nonsurgery controls) were included in the three studies. Two studies included patients with short bowel syndrome and the other included patients with IBD. Large\u2010scale microbiota changes were reported. In general, alpha diversity had decreased amongst patients with ileal surgery. Phylum\u2010level changes included decreased Bacteroidetes and increased Proteobacteria and Fusobacteria in patients with an intestinal resection. Surgery was associated with increased total faecal BAs, cholic acid and chenodeoxycholic acid. There were decreases in deoxycholic acid and glycine and taurine conjugated bile salts. Integrated BA and microbiota data identified correlations with several bacterial families and BA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The BA\/microbiota axis is still a novel area with minimal observational data in surgery. Further mechanistic research is necessary to further explore this and identify its role in improving perioperative outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16837","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T03:53:45Z","timestamp":1704426825000},"page":"243-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of the bile acid\/microbiota axis in ileal surgery: a systematic review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-2469","authenticated-orcid":false,"given":"Tharindu","family":"Senanayake","sequence":"first","affiliation":[{"name":"NHMRC Centre of Research Excellence in Digestive Health  New Lambton Heights New South Wales Australia"},{"name":"Surgical and Perioperative Care Research Program Hunter Medical Research Institute  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute, Immune Health Program  New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samwel","family":"Makanyengo","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Digestive Health  New Lambton Heights New South Wales Australia"},{"name":"Surgical and Perioperative Care Research Program Hunter Medical Research Institute  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute, Immune Health Program  New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Hoedt","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Digestive Health  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute, Immune Health Program  New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridie","family":"Goggins","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Digestive Health  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute, Immune Health Program  New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Surgical and Perioperative Care Research Program Hunter Medical Research Institute  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-9590","authenticated-orcid":false,"given":"Simon","family":"Keely","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Digestive Health  New Lambton Heights New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"},{"name":"Hunter Medical Research Institute, Immune Health Program  New Lambton Heights New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615600116"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-0681-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13333"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"G378","article-title":"The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing. 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