{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T18:26:36Z","timestamp":1750443996585,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to explore how findings of whole\u2010body MRI including diffusion\u2010weighted imaging (DW\u2010MRI) compared to the routine diagnostic workup with CT and\/or <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) positron emission tomography (PET)\/CT in patients with suspected recurrent colorectal cancer (CRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was an exploratory retrospective analysis of 55 patients with a clinical suspicion of recurrent CRC who underwent DW\u2010MRI following CT and\/or FDG\u2010PET\/CT. Two readers in consensus interpreted all clinical imaging reports and converted each described lesion into a confidence score (1\u2009=\u2009definitely benign to 5\u2009=\u2009definitely malignant). DW\u2010MRI findings were compared to the most recent previous CT or PET\/CT. Any discrepant or additional DW\u2010MRI findings were documented and compared with histology and\/or clinical follow\u2010up (if available).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whole\u2010body MRI including diffusion\u2010weighted imaging (DW\u2010MRI) resulted in discrepant\/additional findings in 26\/55 (47%) cases; 23\/37 (62%) compared to previous CT and 3\/18 (17%) compared to previous PET\/CT. These included 10 cases where DW\u2010MRI converted previously inconclusive CT (<jats:italic>n<\/jats:italic>\u2009=\u20098) or PET\/CT (<jats:italic>n<\/jats:italic>\u2009=\u20092) findings into a conclusive diagnosis, one where it contradicted a previous CT diagnosis of recurrence, five where DW\u2010MRI diagnosed recurrent disease not previously reported on CT and 10 cases where DW\u2010MRI detected additional lesions compared to CT (<jats:italic>n<\/jats:italic>\u2009=\u20099) or PET\/CT (<jats:italic>n<\/jats:italic>\u2009=\u20091). Eighty\u2010eight per cent of cases with discrepant\/additional findings concerned patients with recurrent\/metachronous peritoneal metastases. In total, DW\u2010MRI resulted in 42 discrepant\/additional lesions; the DW\u2010MRI diagnosis was correct in 76% of these lesions and incorrect (false positive) in 7%. In the remaining 17%, no standard of reference was available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This explorative study suggests that DW\u2010MRI may be of added value to patients with a clinical suspicion for recurrent CRC, in particular to identify patients with peritoneal metastases. DW\u2010MRI mainly has potential as a \u2018problem\u2010solver\u2019 in patients with inconclusive or negative findings on previous imaging (in particular CT) and to detect additional disease sites in patients already diagnosed with recurrent disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.16840","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T01:59:12Z","timestamp":1703555952000},"page":"290-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Whole\u2010body MRI with diffusion\u2010weighted imaging as an adjunct to<sup>18<\/sup>F\u2010<scp>fluorodeoxyglucose positron emission tomography<\/scp> and <scp>CT<\/scp> in patients with suspected recurrent colorectal cancer"],"prefix":"10.1111","volume":"26","author":[{"given":"Jeroen R. J.","family":"Willemse","sequence":"first","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max J.","family":"Lahaye","sequence":"additional","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels F. M.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brechtje A.","family":"Grotenhuis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend G. J.","family":"Aalbers","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-9912","authenticated-orcid":false,"given":"Geerard L.","family":"Beets","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"},{"name":"Department of Surgical Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Rijsemus","sequence":"additional","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"},{"name":"Department of Surgical Oncology Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Maas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa W.","family":"van Golen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina G. H.","family":"Beets\u2010Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2990-0099","authenticated-orcid":false,"given":"Doenja M. J.","family":"Lambregts","sequence":"additional","affiliation":[{"name":"Department of Radiology, Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School for Oncology and Reproduction Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"American Society of Clinical Oncology.Colorectal Cancer: Statistics.2022Accessed March 01 2023. 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