{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:36Z","timestamp":1772160096761,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Pelvic radiotherapy is limited by dose\u2010dependent toxicity to surrounding organs. The aim of this prospective study was to evaluate the efficacy and safety of intrarectal formalin treatment for radiotherapy\u2010induced haemorrhagic proctopathy (RHP) at the Royal Marsden Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Adult patients were enrolled. Haemoglobin was evaluated before and after formalin treatment. Antiplatelet and\/or anticoagulation treatment and administration of transfusion were recorded. The interval between completion of radiotherapy and the first intrarectal 5% formalin treatment was assessed and the dose of radiotherapy was evaluated. Clinical assessment of the frequency and amount of rectal bleeding (rectal bleeding score 1\u20136) and endoscopic appearance (grade 0\u20133) were classified. Complications were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen patients were enrolled, comprising 13 men (68%) and 6 women. The mean age was 75\u2009\u00b1\u20099\u2009years. The median time between completion of radiotherapy and the first treatment was 20\u2009months [interquartile range (IQR) 15\u2009months] and the median dose of radiotherapy was 68\u2009Gy (IQR 14\u2009Gy). Thirty\u2010two procedures were performed (average 1.7 per patient). In total, 9\/19 (47%) patients were receiving anticoagulation and\/or antiplatelet medication and 5\/19 (26%) received transfusion prior to treatment. The mean value of serum haemoglobin before the first treatment was 110\u2009\u00b1\u200918\u2009g\/L and afterwards it was 123\u2009\u00b1\u200916\u2009g\/L (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). The median rectal bleeding score before the first treatment was 6 (IQR 0) and afterwards 2 (IQR 1\u20134;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while the median endoscopy score on the day of first treatment was 3 (IQR 0) compared with 1 (IQR 1\u20132) on the day of the last treatment 1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). One female patient with a persistent rectal ulcer that eventually healed (18\u2009months of healing) subsequently developed rectovaginal fistula (complication rate 1\/19, 5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with intrarectal formalin in RHP is effective and safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.16956","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:34:30Z","timestamp":1711154070000},"page":"932-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrarectal formalin treatment for haemorrhagic radiation\u2010induced proctopathy: efficacy and safety"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-309X","authenticated-orcid":false,"given":"Darina","family":"Kohoutova","sequence":"first","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Wilson","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust  London UK"},{"name":"St Mark's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Gee","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramy","family":"Elhusseiny","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust  London 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