{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:21Z","timestamp":1787014041725,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to determine the consequences of the new definition of rectal cancer for decision\u2010making in multidisciplinary team meetings (MDT). The new definition of rectal cancer, the lower border of the tumour is located below the sigmoid take\u2010off (STO), was implemented in the Dutch guideline in 2019 after an international Delphi consensus meeting to reduce interhospital variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>All patients with rectal cancer according to the local MDT, who underwent resection in 2016 in the Netherlands were eligible for this nationwide collaborative cross\u2010sectional study. MRI\u2010images were rereviewed, and the tumours were classified as above or on\/below the STO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study registered 3107 of the eligible 3178 patients (98%), of which 2784 patients had an evaluable MRI. In 314 patients, the tumour was located above the STO (11%), with interhospital variation between 0% and 36%. Based on TN\u2010stage, 175 reclassified patients with colon cancer (6%) would have received different treatment (e.g., omitting neoadjuvant radiotherapy, candidate for adjuvant chemotherapy). Tumour location above the STO was independently associated with lower risk of 4\u2010year locoregional recurrence (HR 0.529;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) and higher 4\u2010year overall survival (HR 0.732;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) compared to location under the STO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>By using the STO, 11% of the prior MDT\u2010based diagnosis of rectal cancer were redefined as sigmoid cancer, with potential implications for multimodality treatment and prognostic value. Given the substantial interhospital variation in proportion of redefined cancers, the use of the STO will contribute to standardisation and comparability of outcomes in both daily practice and trial settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.17002","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T04:28:27Z","timestamp":1714364907000},"page":"1131-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of the new rectal cancer definition on multimodality treatment and interhospital variability: Results from a nationwide cross\u2010sectional study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-1986","authenticated-orcid":false,"given":"Sanne\u2010Marije J. A.","family":"Hazen","sequence":"first","affiliation":[{"name":"Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania C.","family":"Sluckin","sequence":"additional","affiliation":[{"name":"Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Horsthuis","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"},{"name":"Radiology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2990-0099","authenticated-orcid":false,"given":"Doenja M. J.","family":"Lambregts","sequence":"additional","affiliation":[{"name":"Radiology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina G. H.","family":"Beets\u2010Tan","sequence":"additional","affiliation":[{"name":"Radiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"GROW School of Oncology and Developmental Biology University of Maastricht  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Hompes","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke E.","family":"Buffart","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Medical Oncology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrie A. M.","family":"Marijnen","sequence":"additional","affiliation":[{"name":"Radiation Oncology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Radiation Oncology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-3310","authenticated-orcid":false,"given":"Pieter J.","family":"Tanis","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"},{"name":"Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Surgical Oncology and Gastrointestinal Surgery Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2468-9186","authenticated-orcid":false,"given":"Miranda","family":"Kusters","sequence":"additional","affiliation":[{"name":"Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch Snapshot Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.06.005"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71199-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032709"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.6771"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010580"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5506"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003251"},{"key":"e_1_2_13_9_1","unstructured":"Available from:https:\/\/richtlijnendatabase.nl\/richtlijn\/colorectaal_carcinoom_crc\/diagnostiek_bij_crc\/locoregionale_stadi_ring_rectumcarcinoom.html. 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