{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:14:15Z","timestamp":1790194455306,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Attention is increasingly being turned to functional outcomes as being central to colorectal cancer (CRC) survivorship. The current literature may underestimate the impact of evacuatory dysfunction on patient satisfaction with bowel function after anterior resection (AR) for CRC. The aim of this study was to investigate the impact of post\u2010AR symptoms of storage and evacuatory dysfunction on patient satisfaction and health\u2010related quality of life (HRQoL).<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A cross\u2010sectional study was performed at an Australian hospital of patients post\u2010AR for CRC (2012\u20132021). The postoperative bowel function scores used were: low anterior resection syndrome (LARS), St Mark's incontinence, Cleveland Clinic constipation and Altomare obstructive defaecation syndrome scores. Eight \u2018storage\u2019 and \u2018evacuatory\u2019 dysfunction symptoms were derived. A seven\u2010point Likert scale measured patient satisfaction. The SF36v2\u00ae measured HRQoL. Linear regression assessed the association between symptoms, patient satisfaction and HRQoL.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, 248 patients participated (mean age 70.8\u2009years, 57.3% male), comprising 103 with rectal cancer and 145 with sigmoid cancer. Of the symptoms that had a negative impact on patient satisfaction, six reflected evacuatory dysfunction, namely excessive straining (\n p<\/jats:italic>\n \u2009<\u20090.001), one or more unsuccessful bowel movement attempt(s)\/24\u2009h (\n p<\/jats:italic>\n \u2009<\u20090.001), anal\/vaginal digitation (\n p<\/jats:italic>\n \u2009=\u20090.005), regular enema use (\n p<\/jats:italic>\n \u2009=\u20090.004), toilet revisiting (\n p<\/jats:italic>\n \u2009=\u20090.004) and >10\u2009min toileting (\n p<\/jats:italic>\n \u2009=\u20090.004), and four reflected storage dysfunction, namely leaking flatus (\n p<\/jats:italic>\n \u2009=\u20090.002), faecal urgency (\n p<\/jats:italic>\n \u2009=\u20090.005), use of antidiarrhoeal medication (\n p<\/jats:italic>\n \u2009=\u20090.001) and incontinence\u2010related lifestyle alterations (\n p<\/jats:italic>\n \u2009<\u20090.001). A total of 130 patients (53.5%) had \u2018no LARS\u2019, 56 (23.1%) had \u2018minor LARS\u2019 and 57 (23.4%) had \u2018major LARS\u2019. Fifty\u2010seven (44.5%) patients classified as having \u2018no LARS\u2019 had evacuatory dysfunction.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Postoperative storage and evacuatory dysfunction symptoms have an adverse impact on patient satisfaction and HRQoL post\u2010AR. The importance of comprehensively documenting symptoms of evacuatory dysfunction is highlighted. Further research is required to develop a patient satisfaction\u2010weighted LARS\u2010specific HRQoL instrument.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.17034","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:07:16Z","timestamp":1716854836000},"page":"1214-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Low anterior resection syndrome phenotypes\u2014Different symptom profiles for different patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-4919","authenticated-orcid":false,"given":"Sireesha","family":"Koneru","sequence":"first","affiliation":[{"name":"Concord Repatriation General Hospital Concord Institute of Academic Surgery Sydney New South Wales Australia"},{"name":"Division of Colorectal Surgery, Department of Surgery Concord Repatriation General Hospital Sydney New South Wales Australia"},{"name":"Discipline of Surgery, School of Medicine, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-4472","authenticated-orcid":false,"given":"Julie","family":"Cornish","sequence":"additional","affiliation":[{"name":"Cardiff and Vale University Health Board Cardiff Wales UK"},{"name":"University Hospital of Wales Cardiff Wales UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre H.","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital Concord Institute of Academic Surgery Sydney New South Wales Australia"},{"name":"Division of Colorectal Surgery, Department of Surgery Concord Repatriation General Hospital Sydney New South Wales Australia"},{"name":"Discipline of Surgery, School of Medicine, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Keshava","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital Concord Institute of Academic Surgery Sydney New South Wales Australia"},{"name":"Division of Colorectal Surgery, Department of Surgery Concord Repatriation General Hospital Sydney New South Wales Australia"},{"name":"Discipline of Surgery, School of Medicine, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J. F. X.","family":"Rickard","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital Concord Institute of Academic Surgery Sydney New South Wales Australia"},{"name":"Division of Colorectal Surgery, Department of Surgery Concord Repatriation General Hospital Sydney New South Wales Australia"},{"name":"Discipline of Surgery, School of Medicine, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheng\u2010Seong","family":"Ng","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital Concord Institute of Academic Surgery Sydney New South Wales Australia"},{"name":"Division of Colorectal Surgery, Department of Surgery Concord Repatriation General Hospital Sydney New South Wales Australia"},{"name":"Discipline of Surgery, School of Medicine, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"743","article-title":"Double stapling technique in the management of rectal tumours","volume":"152","author":"St\u00e5hle E","year":"1986","journal-title":"Acta Chir Scand."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2022.101739"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010020\u201003644\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824f1c21"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468\u20101253(19)30147\u20105"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(12)70236\u2010x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15421"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.06.031"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14818"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002071"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9223"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000080823.38569.b0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201082149\u20109"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15041"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.1.77"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02056950"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101318.2007.01262.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7296.1240"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/dcr.0000000000000036"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312695"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.17034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T03:50:42Z","timestamp":1719460242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.17034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/codi.17034"],"URL":"https:\/\/doi.org\/10.1111\/codi.17034","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"2023-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}