{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:52:43Z","timestamp":1775811163080,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201001103"],"award-info":[{"award-number":["2017\u201001103"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201001025"],"award-info":[{"award-number":["2021\u201001025"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The standard treatment for anal cancer is chemoradiotherapy. Most patients survive anal cancer but remain living with long\u2010term side effects related to the treatment received. The aim of this study was to assess the occurrence of long\u2010term impairment of urinary and sexual function at 3 and 6\u2009years after diagnosis and to investigate the additive effect from chemotherapy in combined chemoradiotherapy on urinary incontinence, compared to radiotherapy alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The ANal CAncer study (ANCA) is based on a national Swedish cohort of patients diagnosed with anal cancer between 2011 and 2013. All identified patients within the study were invited to respond to a study\u2010specific questionnaire at 3 and 6\u2009years. Descriptive analyses for the primary endpoint were performed. To investigate a possible additional effect from chemotherapy logistic regression was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 388 patients were included in the study. At 3\u2009years 264 patients were alive and invited to respond to an anal cancer specific questionnaire. The 3\u2010 and 6\u2009year response rates were 195 (74%) and 155 patients (67%), respectively. The patient reported urinary function impairment at 3\u2009years were urgency (63%), incomplete bladder emptying (47%), and incontinence (46%) and there was an absolute increase of the prevalence of urinary dysfunction in about 10% at 6\u2009years. Three years after diagnosis, 77% reported that intercourse was not part of their sex life; this percentage increased at 6\u2009years to 83%. We found no negative effect of chemotherapy in combined chemoradiotherapy versus radiotherapy alone on patient reported urinary incontinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For anal cancer survivors, urinary function was impaired after 3\u2009years and continued to deteriorate as measured at 6\u2009years after diagnosis. Anal cancer and its treatment negatively affected sexual function for both men and women. This may explain why patients reported that sexual activity and frequency of intercourse was not of importance in their life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.17040","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T23:55:03Z","timestamp":1717113303000},"page":"1359-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patient reported long\u2010term side effects from treatment on urinary and sexual function in anal cancer survivors \u2013 3\u2010 and 6\u2010year results from the Swedish national\n                    <scp>ANCA<\/scp>\n                    study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-4885","authenticated-orcid":false,"given":"Anna","family":"Axelsson","sequence":"first","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Oncology Sahlgrenska University Hospital\/Sahlgrenska  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Oncology Sahlgrenska University Hospital\/Sahlgrenska  Gothenburg Sweden"},{"name":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-5605","authenticated-orcid":false,"given":"Eva","family":"Haglind","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Sahlgrenska University Hospital\/\u00d6stra  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, SSORG\u2010Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0438-5887","authenticated-orcid":false,"given":"Per J.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Division of Coloproctology, Department of Pelvic Center Karolinska University Hospital  Stockholm 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