{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:38Z","timestamp":1791588098632,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The significance of lymphadenectomy and its indications in patients with inguinal lymph node metastasis (ILNM) of anorectal adenocarcinoma is unclear. This study aimed to clarify the surgical outcomes and prognostic factors of inguinal lymphadenectomy for ILNM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study included patients who underwent surgical resection for ILNM of rectal or anal canal adenocarcinoma with pathologically positive metastases between 1997 and 2011 at 20 participating centres in the Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer organized by the Japanese Society for Cancer of the Colon and Rectum. Clinicopathological characteristics and short\u2010 and long\u2010term postoperative outcomes were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 107 patients were included. The primary tumour was in the rectum in 57 patients (53.3%) and in the anal canal in 50 (46.7%). The median number of ILNMs was 2.34. Postoperative complications of Clavien\u2013Dindo Grade III or higher were observed in five patients. The 5\u2010year overall survival rate was 38.8%. Multivariate analysis identified undifferentiated histological type (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), pathological venous invasion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) and pathological primary tumour depth T0\u20132 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) as independent prognostic factors for poor overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 5\u2010year overall survival after inguinal lymph node dissection was acceptable, and it warrants consideration in more patients. Further larger\u2010scale studies are needed in order to clarify the surgical indications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.17054","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T02:19:52Z","timestamp":1718590792000},"page":"1378-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Short\u2010 and long\u2010term outcomes of surgical treatment for inguinal lymph node metastasis in rectal and anal canal adenocarcinoma"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-8171","authenticated-orcid":false,"given":"Sono","family":"Ito","sequence":"first","affiliation":[{"name":"Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Colorectal Surgery National Cancer Center Hospital  Tokyo 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Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Faculty of Medicine, Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Takii","sequence":"additional","affiliation":[{"name":"Study Group for Inguinal Lymph Node Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Gastroenterological Surgery Niigata Cancer Center Hospital  Niigata 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