{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:10:52Z","timestamp":1792221052129,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short\u2010term results of patients who underwent primary ileocaecal resection for either inflammatory (luminal disease, earlier in the disease course) or complicated phenotypes, hypothesizing that the latter would be associated with worse postoperative outcomes.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n A retrospective, multicentre comparative analysis was performed including patients operated on for primary ileocaecal CD at 12 referral centres. Patients were divided into two groups according to indication of surgery for inflammatory (ICD) or complicated (CCD) phenotype. Short\u2010term results were compared.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 2013 patients were included, with 291 (14.5%) in the ICD group. No differences were found between the groups in time from diagnosis to surgery. CCD patients had higher rates of low body mass index, anaemia (40.9% vs. 27%,\n p<\/jats:italic>\n <\u20090.001) and low albumin (11.3% vs. 2.6%,\n p<\/jats:italic>\n <\u20090.001). CCD patients had longer operations, lower rates of laparoscopic approach (84.3% vs. 93.1%,\n p<\/jats:italic>\n \u2009=\u20090.001) and higher conversion rates (9.3% vs. 1.9%,\n p<\/jats:italic>\n <\u20090.001). CCD patients had a longer hospital stay and higher postoperative complication rates (26.1% vs. 21.3%,\n p<\/jats:italic>\n \u2009=\u20090.083). Anastomotic leakage and reoperations were also more frequent in this group. More patients in the CCD group required an extended bowel resection (14.1% vs. 8.3%,\n p<\/jats:italic>\n : 0.017). In multivariate analysis, CCD was associated with prolonged surgery (OR 3.44,\n p<\/jats:italic>\n \u2009=\u20090.001) and the requirement for multiple intraoperative procedures (OR 8.39,\n p<\/jats:italic>\n \u2009=\u20090.030).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Indication for surgery in patients who present with an inflammatory phenotype of CD was associated with better outcomes compared with patients operated on for complications of the disease. There was no difference between groups in time from diagnosis to surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.17056","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:56:09Z","timestamp":1718063769000},"page":"1415-1427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010term outcomes of surgical treatment for primary ileocaecal Crohn's disease: Results of the Crohn's(urg) study, a multicentre, retrospective, comparative analysis between inflammatory and complicated phenotypes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-7125","authenticated-orcid":false,"given":"Nicolas","family":"Avellaneda","sequence":"first","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"},{"name":"General Surgery Department CEMIC Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-6421","authenticated-orcid":false,"given":"Gianluca","family":"Pellino","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences Universit\u00e0 Degli Studi Della Campania \u201cLuigi Vanvitelli\u201d Naples Italy"},{"name":"Colorectal Surgery, Vall d'Hebron University Hospital Universitat Autonoma de Barcelona UAB Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Maroli","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery IRCCS \u2013 Humanitas Research Hospital Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Tottrup","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-9287","authenticated-orcid":false,"given":"Gabriele","family":"Bislenghi","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Leuven University Hospital Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-2802","authenticated-orcid":false,"given":"Jan","family":"Colpaert","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Leuven University Hospital Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"D'Hoore","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Leuven University Hospital Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carvello","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery IRCCS \u2013 Humanitas Research Hospital Milan Italy"},{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery IRCCS \u2013 Humanitas Research Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Juachon","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery IRCCS \u2013 Humanitas Research Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-0909","authenticated-orcid":false,"given":"Sanne","family":"Harsl\u00f8f","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"de Buck\u00a0Van\u00a0Overstraeten","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Sinai Health Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Olivera","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Unit, Gastroenterology Section, Department of Internal Medicine Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas Buenos Aires Argentina"},{"name":"Zane Cohen Centre for Digestive Diseases Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System Toronto Ontario Canada"},{"name":"Division of Gastroenterology, Mount Sinai Hospital University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gomez","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Sinai Health Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-9042","authenticated-orcid":false,"given":"Stefan D.","family":"Holubar","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy Lincango","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Steele","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-7080","authenticated-orcid":false,"given":"Amit","family":"Merchea","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Mayo Clinic Jacksonville 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Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Hahnloser","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djana","family":"Rrupa","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christianne","family":"Buskens","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Amsterdam UMC, Location AMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouck","family":"Haanappel","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department Amsterdam UMC, Location AMC Amsterdam The 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