{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:21Z","timestamp":1787014041114,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Crohn's disease has debilitating effects on patients' quality of life. Currently, there are limited data on the effect of anastomotic configuration on health\u2010related quality of life after ileocaecal resection for Crohn's disease. This study aimed to assess the impact of Kono\u2010S anastomosis on quality of life after ileocolic resection, compared to the conventional side\u2010to\u2010side anastomosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients with primary or recurrent Crohn's disease participating in the ongoing SuPREMe\u2010CD trial were interviewed about quality of life using the Inflammatory Bowel Disease Questionnaire (IBDQ). The primary endpoint was disease\u2010specific quality of life, assessed with IBDQ. Secondary outcomes were quality of life related to bowel symptoms, systemic symptoms, social function and emotional function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 94 patients included, 51 (54%) received the conventional side\u2010to\u2010side anastomosis and 43 (46%) the Kono\u2010S anastomosis. Demographics were comparable between the two groups. The IBDQ was assessed at a mean follow\u2010up of 54.0\u2009\u00b1\u200918.7\u2009months from surgical intervention. The mean total IBDQ score was 155.1\u2009\u00b1\u200928.07 in the conventional group and 163.8\u2009\u00b1\u200925.23 in the Kono\u2010S group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.11). When considering bowel symptoms and social function, mean scores were 50.7 and 23.5 in the conventional group, and 56.3 and 26.5 in the Kono\u2010S group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02, respectively). Kono\u2010S anastomosis was independently associated with improved quality of life regarding bowel symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006) and social function (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) after correcting for other confounding factors on linear regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to conventional side\u2010to\u2010side anastomosis, patients with Kono\u2010S anastomosis presented significantly better bowel symptoms and social function scores at 54\u2009months after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.17073","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T02:24:36Z","timestamp":1718591076000},"page":"1428-1436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Kono\u2010S anastomosis on quality of life after ileocolic resection in Crohn's disease: an analysis from the SuPREMe\u2010CD trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-1504","authenticated-orcid":false,"given":"Michele","family":"Cricr\u00ec","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Endoscopic Surgery Unit University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-1940","authenticated-orcid":false,"given":"Francesca Paola","family":"Tropeano","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Endoscopic Surgery Unit University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rispo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Gastroenterology Unit University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Endoscopic Surgery Unit University of Naples \u2018Federico II\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano Cesare","family":"Giglio","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Hepatobiliary Surgery Unit University of Naples \u2018Federico II\u2019  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