{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:09:51Z","timestamp":1775311791783,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the risk and natural history of developing advanced anal disease after diagnosis of anal condyloma in people living with HIV (PLWH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010centre retrospective cohort study of PLWH and anal condyloma from 2001 to 2021. Patients who developed advanced anal disease (AAD; anal high\u2010grade squamous intraepithelial lesions and\/or anal cancer) were compared to those who did not progress (non\u2010AAD). We assessed the potential association between AAD and condyloma location, recurrence, and treatment modality. AAD\u2010free survival was calculated utilizing Kaplan\u2013Meier methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 118 PLWH and anal condyloma were included. Mean overall follow\u2010up time was 9.3\u2009years. A total of 31% of patients developed AAD (<jats:italic>n<\/jats:italic>\u2009=\u200937). Average time to AAD from condyloma diagnosis was 5.6\u2009years. On multivariate analysis, risk for AAD development was associated with perianal location of condyloma (OR 4.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.038) and increased time from initial condyloma diagnosis (OR 1.12, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Higher CD4\/CD8 ratios were associated with lower risk of AAD (OR 0.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.029). Condyloma recurrence and treatment type were not associated with development of AAD. AAD\u2010free survival was longer in those with intra\u2010anal only condyloma versus those with either perianal disease alone or combined intra\u2010anal\/perianal disease (mean survival times: 22.8 vs. 8.7 vs. 10.7\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates the need for careful, long\u2010term follow\u2010up of PLWH and condyloma, particularly in the setting of perianal disease and low CD4\/CD8 ratio. Risk of anal disease progression is present even in the setting of condyloma regression following treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.17099","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:24:18Z","timestamp":1722831858000},"page":"1693-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk of developing high\u2010grade squamous intraepithelial lesions or anal cancer after anal condylomata treatment in people living with <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9766-6972","authenticated-orcid":false,"given":"Austin","family":"Hewitt","sequence":"first","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Kawak","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery Riverview Health  Noblesville Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Cherney","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard H.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"University of Wisconsin Carbone Cancer Centre  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Striker","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M.","family":"Hayden","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina B.","family":"Sanger","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Department of Surgery William S. Middleton Memorial Veteran's Hospital  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10051047"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462420920142"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11061083"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.02.008"},{"issue":"4","key":"e_1_2_12_6_1","first-page":"1","article-title":"Sexually transmitted infections treatment guidelines","volume":"70","author":"Workowski KA","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.09.09"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002975"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.10.027"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis228"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-053035"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000890"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199033"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-019-01951-w"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13215"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201048"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34850"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.06.029"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001763"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-022-04123-9"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5252"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0242-RA"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001114"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.11.030"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02183-x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix245"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1822"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.17099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T12:05:24Z","timestamp":1731845124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.17099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,4]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/codi.17099"],"URL":"https:\/\/doi.org\/10.1111\/codi.17099","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,4]]},"assertion":[{"value":"2024-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}