{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:18:52Z","timestamp":1777364332331,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Minimal evidence exists regarding faecal immunochemical tests (FITs) for colorectal cancer (CRC) site, stage and grade in symptomatic patients. The primary aim is to determine any association between faecal haemoglobin concentration (f\u2010Hb) (analysed with OC\u2010Sensor\u2122 Pledia) and these prognostic factors. The secondary aim is to determine the association between f\u2010Hb and anaemia, microcytosis and iron deficiency (Hb, mean corpuscular volume [MCV] and ferritin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Symptomatic 2\u2010week wait CRC patients with FIT were included (July 2019\u2013October 2022). Median f\u2010Hb and interquartile range according to sex, stage, grade and site (right\u2010sided, caecum to transverse colon, R\u2010CRC; left\u2010sided, splenic flexure to rectum, L\u2010CRC) were compared using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test. Hb, MCV and ferritin were categorized into two groups and the median f\u2010Hb was compared using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 114 patients (57 women, 57 men) were studied; 46 had R\u2010CRC (f\u2010Hb\u2009=\u2009113\u2009\u03bcg Hb\/g) and 68 had L\u2010CRC (f\u2010Hb\u2009=\u2009342\u2009\u03bcg Hb\/g) (<jats:italic>P<\/jats:italic>\u2009=\u20090.07). Sixty\u2010nine were moderately differentiated CRC (f\u2010Hb\u2009=\u2009183\u2009\u03bcg Hb\/g) and 29 were poorly differentiated (f\u2010Hb\u2009=\u2009866\u2009\u03bcg Hb\/g) (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). By T\u2010stage, 35 were early (T1\/2) (f\u2010Hb\u2009=\u2009170\u2009\u03bcg Hb\/g) and 79 were advanced (T3\/4) (f\u2010Hb\u2009=\u2009200\u2009\u03bcg Hb\/g) (<jats:italic>P<\/jats:italic>\u2009=\u20090.06). The relationship between f\u2010Hb and Hb, MCV and ferritin was not significant. Poorly differentiated (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) and later stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) R\u2010CRC had significantly lower f\u2010Hb compared to L\u2010CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Right\u2010sided CRC is associated with lower f\u2010Hb than left. Poorly differentiated and later staged L\u2010CRC had higher median f\u2010Hb. These data add to existing evidence suggesting that FIT may be less sensitive for right\u2010sided CRC. Strategies to mitigate the potential for missed or FIT\u2010negative right\u2010sided CRC are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.17187","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T04:15:17Z","timestamp":1727324117000},"page":"2039-2045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Faecal haemoglobin concentration and colorectal cancer site, stage and grade in a symptomatic cohort"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4216-4786","authenticated-orcid":false,"given":"Nicholas G.","family":"Farkas","sequence":"first","affiliation":[{"name":"Minimal Access Therapy and Training Unit (MATTU) Royal Surrey Hospital NHS Foundation Trust  Guildford UK"},{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-1876","authenticated-orcid":false,"given":"Kai Shing","family":"Yu","sequence":"additional","affiliation":[{"name":"Minimal Access Therapy and Training Unit (MATTU) Royal Surrey Hospital NHS Foundation Trust  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Whyte","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain","family":"Jourdan","sequence":"additional","affiliation":[{"name":"Minimal Access Therapy and Training Unit (MATTU) Royal Surrey Hospital NHS Foundation Trust  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Rockall","sequence":"additional","affiliation":[{"name":"Minimal Access Therapy and Training Unit (MATTU) Royal Surrey Hospital NHS Foundation Trust  Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally C.","family":"Benton","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Royal Surrey County Hospital, Berkshire and Surrey Pathology Services  Guildford Surrey UK"},{"name":"NHS Bowel Cancer Screening South of England Hub, Berkshire and Surrey Pathology Services Royal Surrey County Hospital  Guildford Surrey 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