{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:59:57Z","timestamp":1784872797874,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Anastomotic leakage following rectal cancer surgery remains a challenging complication, with a nonhealing rate of approximately 50% at 1\u2009year. Pelvic sepsis may require tertiary treatment that encompasses additional admissions, extensive surgery and other types of interventions. The aim of this study is to analyse the financial burden of pelvic sepsis in a tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>From 2010 until 2020, all patients referred to a tertiary centre for pelvic sepsis after low anterior resection for rectal cancer were prospectively registered and retrospectively reviewed. The cost analysis adhered to Dutch National Healthcare Institute guidelines and covered hospital\u2010imposed medical costs from salvage surgery to the last registered intervention, adjusted for inflation and priced in euros.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis included 126 patients, with an average total cost per patient of \u20ac31\u2009131. Salvage surgery accounted for \u20ac21\u2009326, with an additional \u20ac9805 for reinterventions and readmissions. Salvage surgery comprised nonrestorative surgery in 48% and restorative salvage surgery in the remaining cases. Length of hospital stay averaged 9.6\u2009days on the general ward and 0.8\u2009days in the intensive care unit. Common reinterventions included endoscopic vacuum sponge changes (<jats:italic>n<\/jats:italic>\u2009=\u2009153), stoma closures (<jats:italic>n<\/jats:italic>\u2009=\u200959) and radiological abscess drainages (<jats:italic>n<\/jats:italic>\u2009=\u200951). Total costs did not differ significantly between nonrestorative surgery and restorative surgery (mean\u2009=\u2009\u20ac31\u2009950 vs. \u20ac30\u2009362, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.893).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treating pelvic sepsis after rectal cancer resection in a tertiary hospital carries a substantial economic burden, averaging \u20ac31\u2009131 per patient, and this work helps to quantify the potential economic impact of innovative care to reduce anastomotic leakage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.17189","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T04:09:19Z","timestamp":1727237359000},"page":"1922-1930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Economic burden of pelvic sepsis after anastomotic leakage following rectal cancer surgery: A retrospective cost\u2010of\u2010illness analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-1663","authenticated-orcid":false,"given":"Kiedo","family":"Wienholts","sequence":"first","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-8585","authenticated-orcid":false,"given":"David J.","family":"Nijssen","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-2037","authenticated-orcid":false,"given":"Sarah","family":"Sharabiany","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6306-3653","authenticated-orcid":false,"given":"Maarten J.","family":"Postma","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-3310","authenticated-orcid":false,"given":"Pieter J.","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"},{"name":"Department of Surgical Oncology and Gastrointestinal Surgery Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wytze","family":"Lam\u00e9ris","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-8950","authenticated-orcid":false,"given":"Roel","family":"Hompes","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The 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