{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:53:10Z","timestamp":1783039990834,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify patient\u2010reported complaints affecting quality of life in Crohn's disease patients with a perianal fistula, and to compare differences between subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A questionnaire was distributed to 1667 patients from the Dutch Crohn's and Colitis Patients' organization, those patients with Crohn's disease and perianal fistula were included. Patients were asked to report (using free text) their most important fistula\u2010related complaints affecting their quality of life. All responses were structurally analyzed and categorized. Data comparisons were made between subgroups: women versus men, patients with versus without current presence of a seton, and patients aged \u226440 versus &gt;40\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 743 respondents (44.6%), 123 patients with Crohn's disease and perianal fistula were included (92 women, median age 41\u2009years [IQR 34\u201356] and 36 with seton). A total of 776 complaints were allocated to 36 categories, with 19 reported in &gt;10% of patients. Perianal fistula\u2010related complaints affected nearly all patients (95.9%). Impact on psychological status (71.7% vs. 29.0%; <jats:italic>p\u2009&lt;<\/jats:italic>\u20090.0001) and on sexual activities (37.0% vs. 16.1%; <jats:italic>p<\/jats:italic>\u2009=\u20090.003) were more common in women than men. Younger patients more often reported insecurity (38.7% vs. 18.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.026), shame (29.0% vs. 11.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.024), and impact on sexual activities (40.3% vs. 23.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.048) than older patients. Patients with a seton more frequently reported self\u2010experienced malodour (50.0% vs. 23.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.005), physical activity limitations (41.7% vs. 19.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.014), and work\/study impact (22.2% vs. 5.7%; <jats:italic>p<\/jats:italic>\u2009=\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified 19 perianal fistula\u2010related complaints reported by &gt;10% of patients. These complaints may guide improvement of current outcome measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.17207","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T02:58:05Z","timestamp":1729825085000},"page":"2057-2068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of spontaneous patient\u2010reported complaints related to perianal fistula in patients with Crohn's disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2549-617X","authenticated-orcid":false,"given":"Lars","family":"Bootsma","sequence":"first","affiliation":[{"name":"Proctos Kliniek  Bilthoven The Netherlands"},{"name":"Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-6652","authenticated-orcid":false,"given":"Paul F.","family":"Vollebregt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"van Bodegraven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Geriatrics, Internal and Intensive Care Medicine (COMIK) Zuyderland Medical Center  Sittard the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Crohn and Colitis Netherlands (CCNl)  Woerden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid J. M.","family":"Han\u2010Geurts","sequence":"additional","affiliation":[{"name":"Proctos Kliniek  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richelle J. F.","family":"Felt\u2010Bersma","sequence":"additional","affiliation":[{"name":"Proctos Kliniek  Bilthoven The Netherlands"},{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303376"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142481","article-title":"Evolution of costs of inflammatory bowel disease over two years of follow\u2010up","volume":"11","author":"Valk ME","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.03.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2007.06.005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14599"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000148"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31203-X"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199501000-00008"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad214"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15720"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90905-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad037"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-0947-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14660"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320553"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3182099d9e"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab076.559"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315503"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00152-3"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-1935-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02613.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000840"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.806497"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa004"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.242.tezz"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx100"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz185"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.17207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T04:27:26Z","timestamp":1734409646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.17207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/codi.17207"],"URL":"https:\/\/doi.org\/10.1111\/codi.17207","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"2024-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}