{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:21Z","timestamp":1787014041352,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The progression of high\u2010grade squamous intraepithelial lesions (HSILs) to anal cancer is feared. Data on the remission of HSILs are scarce, and factors associated with remission have not been identified. The aims of this study were to determine the rate of remission of HSILs and to identify factors associated with remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Consecutive patients with HSILs referred to a tertiary proctology unit for monitoring were identified in a prospective database. Clinical data, as well as cytological, histological and treatment data, were recorded. The remission of HSILs was defined by the normality of the macroscopic examination and the normal histology and\/or cytology of at least two consecutive samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 144 patients with HSILs were followed for 4.1 (2.1\u20136.5) years. The cumulative probabilities of remission of HSILs were 9.7% (6.2%\u201314.9%), 14.6% (10.1%\u201320.7%) and 23.8% (17.3%\u201331.8%) at 2, 3 and 5\u2009years, respectively. Human papillomavirus 16 (HPV16) clearance was achieved in 19\/84 (22.6%) patients. Multivariate analysis revealed that three main factors were associated with remission of HSILs: absence of HPV16 at referral [hazard ratio (HR) 0.3, 95% CI 0.1\u20130.9], location (absence of endoanal lesion) of HSILs (HR 0.1, 95% CI 0.01\u20130.08) and excision of HSILs (HR 3.2, 95% CI 1.1\u20139.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The remission of HSILs was not a frequent event in this long\u2010term cohort study. HPV16 is a pejorative factor, while other high\u2010risk HPVs are not. Excision of the HSIL, when possible, could be a preferred treatment to allow better remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70053","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:07:32Z","timestamp":1741730852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010grade intraepithelial lesions of the anus\u2014patience: A road to wisdom"],"prefix":"10.1111","volume":"27","author":[{"given":"C.","family":"Gouriou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Landemaine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carlo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Boisteau","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Henno","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy and Cytology, CHU Rennes University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Thibault","sequence":"additional","affiliation":[{"name":"Department of Virology, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Sant\u00e9, Environnement et Travail)\u2010UMR_S 1085 University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lievre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes, Inserm, Regional Cancer Center Eug\u00e8ne Marquis, Chemistry Oncogenesis Stress Signaling\u2010UMR1242 University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CHU Rennes, INSERM, CIC1414, Institut NUMECAN (Nutrition Metabolism and Cancer) University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"C.","family":"Brochard","sequence":"additional","affiliation":[{"name":"Department of Physiology Digestive Disease, CHU Rennes, INSERM, CIC1414, Institut NUMECAN (Nutrition Metabolism and Cancer) University of Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24215"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-023-02899-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001947"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000062"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa166"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000505"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000644"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001219"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201048"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac581"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T08:09:15Z","timestamp":1749456555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/codi.70053"],"URL":"https:\/\/doi.org\/10.1111\/codi.70053","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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