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However, in cases of left colon or rectal cancer requiring high vessel ligation for oncological reasons, anastomotic blood supply relies mainly on the pericolic arterial arcades. Consequently, assessing anastomotic perfusion using intraoperative fluorescence angiography with indocyanine green might be relevant to reduce the risk of AL. Although evidence of its positive impact on the risk of AL is growing in the literature, most studies are descriptive prospective cohorts or retrospective comparative series with controversial findings. Furthermore, no other studies specifically address left\u2010sided colon or high rectal tumours. FLUOCOL\u20101 is a large multicentre randomized controlled trial (RCT) that aims to demonstrate that assessing anastomotic perfusion using intraoperative fluorescence angiography with indocyanine green will reduce ALs in left\u2010sided or high anterior resections with intraperitoneal anastomosis<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>FLUOCOL\u20101 is a French multicentre, single\u2010blind, randomized, two\u2010arm, phase III superiority clinical trial. Patients will be randomized in a 1:1 ratio to either the intervention group (FLUO+) or the control group (FLUO\u2212). A total of 1010 patients will be randomized. The primary endpoint is the occurrence of an AL within 90\u2009days postsurgery. AL is defined as any anastomotic dehiscence with leakage into the pelvic cavity diagnosed by imaging or surgical exploration, or any isolated pelvic organ\u2010space infection with no evidence of fistula, as defined by the International Study Group of Rectal Cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Prevention of AL is one of the most important questions to be addressed in colorectal surgery. The FLUOCOL\u20101 multicentre RCT described herein aims to demonstrate that assessment of anastomotic perfusion using intraoperative fluorescence angiography with indocyanine green will reduce ALs in certain resections with intraperitoneal anastomosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.70119","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:54:19Z","timestamp":1748238859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intraoperative indocyanine green fluorescence angiography in colorectal surgery to prevent anastomotic leakage: A single\u2010blind phase <scp>III<\/scp> multicentre randomized controlled trial (<scp>FLUOCOL<\/scp>\u201001\/<scp>FRENCH<\/scp> 21\/<scp>GRECCAR<\/scp> 19 intergroup trial)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-3566","authenticated-orcid":false,"given":"Jean\u2010Baptiste","family":"Pretalli","sequence":"first","affiliation":[{"name":"Department of Digestive Surgical Oncology\u2014Liver Transplantation Unit University Hospital of Besan\u00e7on  Besan\u00e7on France"},{"name":"INSERM CIC 1431, Centre d'Investigation Clinique University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-926X","authenticated-orcid":false,"given":"Dewi","family":"Vernerey","sequence":"additional","affiliation":[{"name":"Methodology and Quality of Life Unit in Oncology University of Besan\u00e7on  Besan\u00e7on France"},{"name":"INSERM, Etablissement Fran\u00e7ais du Sang Bourgogne Franche\u2010Comt\u00e9, UMR1098, Interactions H\u00f4te\u2010Greffon\u2010Tumeur\/Ing\u00e9nierie Cellulaire et G\u00e9nique  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Evrard","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgical Oncology\u2014Liver Transplantation Unit University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-1112","authenticated-orcid":false,"given":"Astrid","family":"Pozet","sequence":"additional","affiliation":[{"name":"D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-6771","authenticated-orcid":false,"given":"Anne\u2010Laure","family":"Clairet","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-7894","authenticated-orcid":false,"given":"St\u00e9phane","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery and Surgical Oncology Bic\u00eatre Hospital  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-7321","authenticated-orcid":false,"given":"Mehdi","family":"Karoui","sequence":"additional","affiliation":[{"name":"Digestive and Oncological Surgery Department Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges\u2010Pompidou, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-5655","authenticated-orcid":false,"given":"Eddy","family":"Cotte","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncological Surgery Lyon Sud University Hospital, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-9131","authenticated-orcid":false,"given":"Bruno","family":"Heyd","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgical Oncology\u2014Liver Transplantation Unit University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-5896","authenticated-orcid":false,"given":"Zaher","family":"Lakkis","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgical Oncology\u2014Liver Transplantation Unit University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FLUOCOL Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Sant\u00e9 publique France.Cancer du colon rectum. 2021 [cited 2021 Jul 26]. 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