{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:01:42Z","timestamp":1788494502374,"version":"build-2803163510"},"reference-count":91,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The primary aim was to develop a patient\u2010centred core outcome set (COS) for interventional studies in patients with pouch anal and vaginal fistula (PAVF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>PAVFCOS was developed using the methodology outlined by the Core Outcome Measures in Effectiveness Trials (COMET). Systematic review and qualitative patient interviews produced a long list of candidate outcomes. An online Delphi exercise was conducted with stakeholders to prioritise and shortlist outcomes. A consensus meeting of patients and clinicians ratified the final core outcome set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A systematic review of the literature and 14 qualitative patient interviews produced a long list of 99 outcomes. These were reduced to 46 outcomes and subjected to two rounds of a Delphi exercise with 70 participants, including patients (45%), colorectal surgeons (31%), radiologists (6%), gastroenterologists (11%) and pouch specialist nurses (7%). Thirty\u2010six outcomes were discussed in a consensus meeting of seven clinicians and seven patients. Seven core outcomes were selected for inclusion: global assessment of continence, pain related to fistula and surrounding area, impact on quality of life of fistula discharge, fistula healing (clinical and radiological), new fistula or abscess, need for rescue intervention (minor or major) and global quality\u2010of\u2010life assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PAVFCOS is the first to establish outcomes that are important to patients with pouch anal and vaginal fistula. PAVFCOS should be used in interventional studies to introduce much\u2010needed standardisation of outcome reporting in this challenging condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70184","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T01:34:01Z","timestamp":1754703241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>PAVFCOS<\/scp>\n                    : The development of a core outcome set for pouch anal and vaginal fistula"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-2989","authenticated-orcid":false,"given":"Lillian","family":"Reza","sequence":"first","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-3449","authenticated-orcid":false,"given":"Lara","family":"Bapir","sequence":"additional","affiliation":[{"name":"West Middlesex University Hospital  Isleworth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Sackitey","sequence":"additional","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hughes","sequence":"additional","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Babbar","sequence":"additional","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rali","family":"Marinova","sequence":"additional","affiliation":[{"name":"IBD Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petya","family":"Marinova","sequence":"additional","affiliation":[{"name":"IBD Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearl","family":"Avery","sequence":"additional","affiliation":[{"name":"IBD Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Lung","sequence":"additional","affiliation":[{"name":"Robin Phillips Fistula Research Unit St Mark's Hospital, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Segal","sequence":"additional","affiliation":[{"name":"The Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"The University of Melbourne Melbourne Medical School  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-9213","authenticated-orcid":false,"given":"P\u00e4r","family":"Myrelid","sequence":"additional","affiliation":[{"name":"Department of Surgery in Link\u00f6ping, and Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gionchetti","sequence":"additional","affiliation":[{"name":"IBD Unit, Department of Medical and Surgical Sciences, S. 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