{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:41:20Z","timestamp":1791819680607,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Perineal wound complications occur frequently after proctectomy in patients with inflammatory bowel disease (IBD), with persistent perineal wounds appearing in some patients. This study examines the surgical outcomes after proctectomy in patients with IBD in a contemporary setting, with primary perineal wound healing as the primary end\u2010point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multicentre retrospective cohort study with five Swedish hospitals participating. Patients with IBD who had undergone proctectomy during the period of 2000\u20132019 were included. Two exposures of interest were analysed: type of IBD, either ulcerative colitis (UC) or Crohn's disease (CD), and indication for surgery. Perineal wound healing was assessed at 3, 6, 12, and 24\u2009months postoperatively. Multilevel binomial regression with complementary log\u2013log link function was used to estimate healing over discrete time intervals, and a separate analysis concerning fistulising disease and healing was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 408 patients (57% males, 56% with UC) were included. Refractory proctitis was the most common indication for surgery in both UC (50%) and CD (38%) patients.<\/jats:p>\n                    <jats:p>\n                      The 2\u2010year overall healing rate was 91%, with 95% in the UC group and 86% in the CD group. Patients with CD had a significantly slower adjusted healing rate (HR 0.67, 95% CI 0.53; 0.85). Anal fistulas as an indication for proctectomy showed significantly lower odds of healing over the entire period compared with proctitis (OR\u2009=\u20090.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perineal wound morbidity with formation of chronic sinuses remains a problem after proctectomy in patients with IBD, primarily in patients with CD and especially those with anal fistulas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70227","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T04:11:06Z","timestamp":1757995866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term perineal wound healing and re\u2010operation rates after proctectomy in patients with inflammatory bowel disease\u2014A retrospective multicentre study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-305X","authenticated-orcid":false,"given":"John","family":"Berghog","sequence":"first","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital\/\u00d6stra  Gothenburg Sweden"},{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-698X","authenticated-orcid":false,"given":"Maria","family":"Hermanson","sequence":"additional","affiliation":[{"name":"Department of Surgery Sahlgrenska University Hospital\/\u00d6stra  Gothenburg Sweden"},{"name":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-0473","authenticated-orcid":false,"given":"Anton","family":"Risto","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Linkoping Sweden"},{"name":"Department of Surgery Link\u00f6ping University  Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University  Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Str\u00f6mb\u00e4ck","family":"Eklund","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Unger","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hagavall","sequence":"additional","affiliation":[{"name":"Department of Surgery Ryhov County Hospital  Jonkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Landerholm","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Linkoping Sweden"},{"name":"Department of Surgery Link\u00f6ping University  Linkoping Sweden"},{"name":"Department of Surgery Ryhov County Hospital  Jonkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malmo Sweden"},{"name":"Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Nordenvall","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Colorectal Surgery Unit, Department of Pelvic Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-9213","authenticated-orcid":false,"given":"P\u00e4r","family":"Myrelid","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences Link\u00f6ping University  Linkoping Sweden"},{"name":"Department of 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