{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:04:49Z","timestamp":1770138289094,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Appendix neuroendocrine tumours (ANETs) carry variable risk depending on histopathological risk factors. Completion right hemicolectomy (RH) is recommended for tumours over 2\u2009cm, with those under 1\u2009cm considered cured by appendectomy. Evidence for RH in ANETs between 1 and 2\u2009cm is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine if a non\u2010surgical approach is appropriate for patients with well\u2010differentiated 1\u20132\u2009cm ANETs, alongside reviewing outcomes for under 1\u2009cm and over 2\u2009cm tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study of all ANETs resected by index appendicectomy in Auckland between 1995 and 2012, using the New Zealand NETwork! registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and four patients with ANETs met inclusion criteria; 157 under 1\u2009cm (77%), 40 between 1 and 2\u2009cm (20%), 7 over 2\u2009cm (3.4%). RH was performed in 20 patients, seven in the under 1\u2009cm cohort, 9 in the 1\u20132\u2009cm cohort and 4 in the over 2\u2009cm cohort. One patient with an over 2\u2009cm ANET had subsequent RH histology demonstrating lymph node metastasis. Follow\u2010up was radiological, median follow\u2010up 62\u2009months (range 2\u2013204). Eight 1\u20132\u2009cm ANETs had histological risk factors but did not undergo RH and had no evidence of recurrence or metastasis on follow\u2010up. No patients died from their ANET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients' with ANETs under 2\u2009cm did not exhibit metastases. Our data support RH in patients' with ANETs over 2\u2009cm and a more conservative approach in those under 2\u2009cm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70239","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:15:51Z","timestamp":1759313751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Appendiceal neuroendocrine tumours, when to operate?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-9398","authenticated-orcid":false,"given":"Imogen","family":"Watt","sequence":"first","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0065-1793","authenticated-orcid":false,"given":"Luke","family":"Henry","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamish","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-6199","authenticated-orcid":false,"given":"Braden","family":"Woodhouse","sequence":"additional","affiliation":[{"name":"The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001590"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13332"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443165"},{"key":"e_1_2_12_5_1","unstructured":"Neuroendocrine Tumors Available online at NCCN.org\/patients. NCCN guidelines for patients [Internet]. [cited 2024 September 15]. Available from:https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/neuroendocrine\u2010patient.pdf"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010300831"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.02.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ebb2a5"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712313172704"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893\u2010023\u201002183\u20104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010295"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(22)00750\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21840"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061357"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.01.005"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487697"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1921262"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010020\u201002356\u20108"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478742"},{"key":"e_1_2_12_21_1","unstructured":"North American Neuroendocrine Tumor Society (NANETS).The NANETS guidelines compendium: 2020 Edition.2020https:\/\/nanets.net\/images\/2020_Guidelines_Compendium.pdf"},{"key":"e_1_2_12_22_1","unstructured":"UK and Ireland Neuroendocrine Tumour Society (UKINETS).Bitesize Guidance: Appendix NETs 2020.https:\/\/www.ukinets.org\/wp\u2010content\/uploads\/UKINETS\u2010bitesize\u2010guidance\u2010Appendix\u2010NETs.pdf"},{"key":"e_1_2_12_23_1","unstructured":"UK and Ireland Neuroendocrine Tumour Society (UKINETS) British Society of Gastroenterology (BSG).Guidance: Appendiceal NETs 2020.https:\/\/www.ukinets.org\/wp\u2010content\/uploads\/UKINETS\u2010BSG\u2010Appendiceal\u2010NETs\u2010FINAL\u2010MS.pdf"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12264"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010019\u201007637\u20109"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002939"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2914"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21634"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022\u2010023\u201009755\u20103"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20362"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.70239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.70239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:41:59Z","timestamp":1770097319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.70239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/codi.70239"],"URL":"https:\/\/doi.org\/10.1111\/codi.70239","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70239"}}