{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:19:55Z","timestamp":1789147195270,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012558","name":"Sk\u00e5ne County Council's Research and Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009736","name":"Allm\u00e4nna Sjukhusets i Malm\u00f6 Stiftelse f\u00f6r Bek\u00e4mpande av Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Anal squamous cell carcinoma (ASCC) is primarily treated with chemoradiotherapy (CRT), but surgery can be curative following treatment failure. The treatment of ASCC was centralised in Sweden in 2017. This study aims to describe the characteristics and outcomes of surgery for ASCC nationally, focusing on short\u2010term morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>All patients with ASCC who underwent surgery from 2017 to 2021 in Sweden were retrospectively identified. Perioperative complications and mortality rates were recorded, and risk factors were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 97 patients underwent 103 surgical procedures. The median age was 64\u2009years (56\u201374), and 61% were women. Indications included recurrent tumours after CRT (43%), residual disease (34%), re\u2010recurrence following prior salvage surgery (8%), primary surgery due to CRT contraindication (8%) and post\u2010treatment sequelae (8%). Surgical procedures included 84 (82%) abdominoperineal excisions, 10 (10%) pelvic exenterations, 5 (5%) perineal excisions for local re\u2010recurrences and 4 (4%) lymphadenectomies.<\/jats:p>\n                    <jats:p>Overall, 48% of patients experienced perineal morbidity, defined as perineal wound infection, dehiscence, necrosis or pelvic abscess. Major surgical complications (Clavien\u2010Dindo \u2265 III) were reported in 22\/103 (21%) of procedures. Most reoperations (9\/16) were related to flap complications. Thirty\u2010 and 90\u2010day mortality rates were 0% and 1%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This national cohort study presents the largest recent series of surgically treated ASCC patients in Sweden. Surgery caused substantial short\u2010term morbidity, particularly perineal morbidity, while short\u2010term mortality remained low. Although no significant risk factors for major complications were identified, these findings highlight the need for improved perineal wound management and further evaluation of long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70241","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T16:00:33Z","timestamp":1759507233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short\u2010term morbidity and mortality following surgical treatment of anal squamous cell carcinoma in Sweden \u2013 A national multicentre study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-5122","authenticated-orcid":false,"given":"Stephanie","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital, Malm\u00f6, Lund University  Lund 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