{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:24Z","timestamp":1787014044830,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Total proctocolectomy (TPC) with ileal pouch\u2010anal anastomosis (IPAA) is the standard surgical treatment for patients with ulcerative colitis refractory to medical therapy. While its impact on bowel function is well documented, its effects on sexual function remain controversial. This study aimed to evaluate changes in sexual function, psychological outcomes (anxiety, depression and fatigue) and quality of life (QoL) after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicentre cohort study included patients undergoing IPAA. Sexual function was assessed using the IIEF\u20105 (men) and FSFI (women). Psychological status, fatigue and QoL were evaluated using the HADS, FSS and SIBDQ, respectively. Validated patient\u2010reported outcome measures were collected at baseline and 6\u201312\u2009months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 332 patients were included. Male sexual function remained stable: 50% reported erectile dysfunction (ED) at baseline with no significant change postoperatively. Female sexual function improved significantly, particularly in desire (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and arousal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Anxiety and depression (HADS) decreased significantly over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as did fatigue (FSS \u22654 dropping from 43% to 25%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). QoL improved markedly, with the proportion of patients reporting poor QoL (SIBDQ &lt;45) reduced threefold at 12\u2009months (p\u2009&lt;\u20090.001). Depressive symptoms were strongly associated with ED in men (OR\u2009=\u200914.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), while disease extent had no significant effect on sexual function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IPAA was associated with significant improvement in psychological well\u2010being, fatigue and QoL, with notable improvements in sexual function among women. However, persistent sexual dysfunction\u2014particularly in women and in men with depressive symptoms\u2014underscores the need for tailored psychological support in the perioperative period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70246","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:35:21Z","timestamp":1759401321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of total proctocolectomy with ileal pouch\u2010anal anastomosis on sexual function, psychological well\u2010being and quality of life in ulcerative colitis: A prospective cohort from the GETAID chirurgie group"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-3836","authenticated-orcid":false,"given":"Barbara","family":"Noiret","sequence":"first","affiliation":[{"name":"Bordeaux Colorectal Institute Tivoli Clinic  Bordeaux 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