{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:55:36Z","timestamp":1781114136254,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/0013;PI18\/01181"],"award-info":[{"award-number":["PI13\/0013;PI18\/01181"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/252"],"award-info":[{"award-number":["PI21\/252"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/01692"],"award-info":[{"award-number":["PI13\/01692"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01589"],"award-info":[{"award-number":["PI18\/01589"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD22\/0053"],"award-info":[{"award-number":["CD22\/0053"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Epidemiological evidence has identified Type 2 Diabetes Mellitus (T2DM) as a risk factor for CRC. This study aimed to evaluate the impact of T2DM, along with clinicopathological and socio\u2010demographic factors, on long\u2010term overall survival in a large, nationally representative cohort of CRC patients with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A prospective cohort of 1186 CRC patients was analysed, approximately 20% of whom had a diagnosis of T2DM. Kaplan\u2013Meier estimates and multivariable Cox proportional hazards models were used to assess overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRC patients with T2DM were more often older, had lower educational attainment, were former smokers, and presented higher comorbidity, right\u2010sided tumours, prior symptoms, depressive symptoms, elevated Body Mass Index (BMI) and lower baseline quality of life (EORTC QLQ\u2010C30\u2009&lt;\u200975). In multivariable analysis, the co\u2010occurrence of T2DM and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007; HR 1.77; 95% CI: 1.17\u20132.68) and low quality of life (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04; HR 1.42; 95% CI: 1.02\u20131.97) emerged as independent predictors of poorer long\u2010term survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight the compounded negative impact of T2DM and depression on overall survival in CRC patients. Their combined presence significantly worsens prognosis, underscoring the need for integrated care approaches that address both physical and mental health. Future research should explore targeted interventions for these comorbidities to improve long\u2010term outcomes and quality of life in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70250","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:32:32Z","timestamp":1759815152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term prognostic implications of type 2 diabetes mellitus in colorectal cancer patients"],"prefix":"10.1111","volume":"27","author":[{"given":"Julia","family":"Alcaide\u2010Garcia","sequence":"first","affiliation":[{"name":"Servicio de Oncolog\u00eda M\u00e9dica Hospital Regional Universitario de M\u00e1laga  M\u00e1laga Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanonmedicina\u2010IBIMA Plataforma Bionand  M\u00e1laga 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Medicine University of Malaga  Malaga Spain"},{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Rivas\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urko","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"},{"name":"Communication Engineering, Research Unit, Osakidetza Basque Health Service, Barrualde\u2010Galdakao Integrated Health Organisation Galdakao\u2010Usansolo Hospital  Galdakao Spain"},{"name":"Biosistemak Institute for Health System Research  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree Mart\u00edn","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanonmedicina\u2010IBIMA Plataforma Bionand  M\u00e1laga Spain"},{"name":"Department of Biochemistry, Molecular Biology and Immunology, Faculty of Medicine University of Malaga  Malaga Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Padilla\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Varela\u2010Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanonmedicina\u2010IBIMA Plataforma Bionand  M\u00e1laga Spain"},{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Robles\u2010Lasarte","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Costa del Sol University Hospital  Marbella Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Bar\u00e9","sequence":"additional","affiliation":[{"name":"Network for Research on 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Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine. Faculty of Pharmacy and Food Sciences. Universitat de Val\u00e8ncia, Spain; CIBER of Epidemiology and Public Health (CIBERESO), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"},{"name":"Research Unit Galdakao\u2010Usansolo University Hospital  Galdakao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanonmedicina\u2010IBIMA Plataforma Bionand  M\u00e1laga Spain"},{"name":"Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximino","family":"Redondo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanonmedicina\u2010IBIMA Plataforma Bionand  M\u00e1laga Spain"},{"name":"Department of Biochemistry, Molecular Biology and Immunology, Faculty of Medicine University of Malaga  Malaga Spain"},{"name":"Research and Innovation Unit Costa del Sol University Hospital  Marbella Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS) Carlos III Health Institute  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_12_4_1","volume-title":"Las Cifras del C\u00e1ncer en Espa\u00f1a 2025 \u201cThe cancer figures in Spain 2025\u201d","author":"SEOM: Sociedad Espa\u00f1ola de Oncolog\u00eda M\u00e9dica","year":"2025"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad450"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.43333"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-019-03345-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1125745"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076813512121"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0473"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24561"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01597-9"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqu024"},{"key":"e_1_2_12_16_1","volume-title":"EORTC QLQ\u2010C30. 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