{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:39:17Z","timestamp":1770136757135,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Prepouch ileitis (PPI) is inflammation of the ileum proximal to an ileoanal pouch, usually associated with pouchitis. The treatment of PPI as a specific entity is poorly studied, and long\u2010term follow\u2010up data are lacking. We aimed to describe the long\u2010term outcomes of biologic therapy in a large, multi\u2010centre, multi\u2010national cohort of patients with PPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an observational, retrospective, multi\u2010centre, multi\u2010national study. We included patients with an endoscopic diagnosis of PPI, treated with biologic medications, who had a follow\u2010up of at least 1\u2009year after biologic treatment initiation. The primary outcome was first\u2010line biologic treatment discontinuation during the study period. The secondary outcome was pouch failure, defined by the need for a defunctioning ileostomy and\/or pouch excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 71 patients in our cohort. Average follow\u2010up length was 101.1\u2009months (\u00b154.5\u2009months). Infliximab was first\u2010line treatment in 42 patients (59.2%), whereas 26 (36.6%) initially received Adalimumab and 3 (4.2%) received Vedolizumab treatment. At the end of the study period, only 16\/71 patients (22.5%) were still on first\u2010line biologic treatment. Persistence rates for infliximab (7\/42, 16.7%) and adalimumab (7\/26, 26.9%) were similar (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.30). Out of 55 patients discontinuing first\u2010line biologic treatment, 26 (36.6% of the cohort) developed pouch failure, and 29 (40.8%) are currently treated with a different medication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>First\u2010line biologic treatment for PPI is associated with high rates of treatment discontinuation. A significant proportion of PPI patients initially treated with biologics develop pouch failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70252","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:54:44Z","timestamp":1759506884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term outcomes of biologic therapy for the treatment of prepouch ileitis: A multi\u2010centre multi\u2010national retrospective study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-5686","authenticated-orcid":false,"given":"Itai","family":"Ghersin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology St. Mark's National Bowel Hospital and Academic Institute  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Calini","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Koifman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Rambam Health Care Campus  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Fischman","sequence":"additional","affiliation":[{"name":"Department of Military Medicine, Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Bowel Disease and Ileoanal Pouch Surgery Centre Chelsea and Westminster Hospital  London UK"},{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Melbourne Hospital  Melbourne Australia"},{"name":"Department of Medicine University of Melbourne  Parkville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orestis","family":"Argyriou","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"},{"name":"Department of Colorectal Surgery St Mark's National Bowel Hospital and Academic Institute  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Royal Bournemouth Hospital  Bournemouth 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