{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:53:38Z","timestamp":1791680018759,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer\u2010related death. Colonoscopy (CO) is the gold standard for screening, but its invasive nature and low adherence limit its use. Second\u2010generation capsule endoscopy (CCE\u20102) emerges as a non\u2010invasive alternative. This study aimed to evaluate the diagnostic accuracy of CCE\u20102 in detecting colorectal polyps, using CO as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis of prospective studies in adults undergoing CCE\u20102 followed by CO was performed. Searches were conducted in PubMed, EMBASE and Cochrane up to May 2025. Diagnostic accuracy metrics were pooled using a Bayesian bivariate model with construction of HSROC curves. To assess clinical impact, a fictitious cohort of 1000 patients was simulated based on polyp prevalence and submitted to decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies including 4316 patients were analysed. CCE\u20102 demonstrated sensitivity\/specificity of 0.89\/0.94 for polyps \u22656\u2009mm and 0.91\/0.98 for \u226510\u2009mm. In FIT\u2010positive patients, performance was superior. In the simulated cohort, CCE\u20102 showed greater net benefit from a 20% pre\u2010test probability threshold of a patient to have a polyp of any size, surpassing the universal CO strategy, avoiding unnecessary colonoscopies to make this diagnostic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCE\u20102 is a non\u2010invasive, safe and accurate alternative for CRC screening, with potential to increase adherence, particularly in patients with contraindications or refusal of CO. However, the lack of therapeutic capability and absence of evidence regarding mortality reduction limit its role as a first\u2010line tool. Randomized clinical trials are needed to consolidate its role in personalized screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70362","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:34:56Z","timestamp":1768912496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Second\u2010generation capsule endoscopy for the detection of colorectal polyps: An updated systematic review and comparative meta\u2010analysis of prospective studies"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2152-210X","authenticated-orcid":false,"given":"Cau\u00e3 Ferreira","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Robson 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