{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:46:02Z","timestamp":1772999162561,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This retrospective observational cohort study aimed to investigate the prevalence of suspected lateral lymph node metastases (LLNM), as diagnosed by magnetic resonance imaging (MRI), and its impact on local recurrence (LR) and overall survival (OS). Patients who underwent dissection of suspected lymph nodes were evaluated in subgroup analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients diagnosed with rectal cancer in Sweden between 2017 and 2021 were identified through the Swedish colorectal cancer registry and grouped by MRI findings. Main outcome measures were LR at 3\u2009years and OS at 3 and 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 2779 patients were analysed. Frequency of lateral lymph node (LLN) enlargement on MRI was 9.4%. In univariable analysis, the risk of LR at 3\u2009years was increased in LLN\u2010positive patients, HR 2.79 (CI 1.55\u20135.03). In multivariable analysis, adjusted for patient, tumour and neoadjuvant treatment factors, this difference remained (HR 1.97 (CI 1.04\u20133.73)). No difference in 3\u2010year OS was observed. At 5\u2009years, univariable analysis indicated increased mortality in LLN\u2010positive patients (HR 1.64 (CI 1.24\u20132.17)), but not in multivariable analysis.<\/jats:p>\n                    <jats:p>Among LLN\u2010positive patients, those who had undergone LLN dissection (LLND) had an LR rate of 12.5% and increased risk at 3\u2009years in univariable analysis (HR 3.73 (CI 1.93\u201310.76)). However, in multivariable analysis, there was no difference in LR risk or OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI\u2010detected LLN positivity is associated with a higher risk of LR and correlates with other adverse prognostic factors. The effect of LLND on LR remains unclear. Further research is needed to optimize treatment strategies for patients with suspected LLNM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70377","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:08:53Z","timestamp":1769486933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The significance of\n                    <scp>MRI<\/scp>\n                    \u2010detected lateral lymph node metastasis in rectal cancer on local recurrence and survival\u2014A nationwide cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-2336","authenticated-orcid":false,"given":"Erik","family":"Agger","sequence":"first","affiliation":[{"name":"Faculty of Medicine Lund University  Lund Sweden"},{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-7843","authenticated-orcid":false,"given":"Cecilia","family":"Dahlb\u00e4ck","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Lund University  Lund Sweden"},{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2801-5362","authenticated-orcid":false,"given":"Cedric","family":"Delorme","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-5552","authenticated-orcid":false,"given":"Pamela","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Lund University  Lund Sweden"},{"name":"Department of Surgery Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11925"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12047"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27317"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000834"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4975"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182565d9d"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10949"},{"key":"e_1_2_13_9_1","first-page":"73","article-title":"Significance, diagnosis and treatment of lateral lymph nodes in rectal cancer: a systematic review","volume":"21","author":"Gulevski S","year":"2019","journal-title":"IJS Open"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-020-03623-w"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9696-x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010815)92:4<896::AID-CNCR1398>3.0.CO;2-R"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195815"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11513"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00032"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002212"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005589"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1101-6"},{"key":"e_1_2_13_19_1","unstructured":"Nationellt v\u00e5rdprogram tjock\u2010 och \u00e4ndtarmscancer \u2010 RCC Kunskapsbanken. 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