{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:48:08Z","timestamp":1784011688360,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Anastomotic leak remains a serious complication after left\u2010sided colorectal resection with substantial morbidity, mortality and healthcare costs. This systematic review and meta\u2010analysis evaluated whether intraoperative indocyanine green (ICG) fluorescence angiography reduces anastomotic leak rates in patients undergoing left\u2010sided colorectal resections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of major databases and trial registries was conducted for RCTs comparing ICG angiography with standard visual assessment in adults undergoing elective left\u2010sided colorectal resection. The primary outcomes were overall and clinically significant (ISGRC Grade B\/C) anastomotic leak. Risk ratios (RRs) were pooled using a random\u2010effects model. Risk of bias was assessed with the Cochrane ROB2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten trials involving 3,772 patients were included. ICG fluorescence angiography, compared to control, reduced overall anastomotic leak (RR 0.62, 95% CI 0.53\u20130.73;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%; prediction interval 0.50\u20130.77) and clinically significant leak (RR 0.66, 95% CI 0.51\u20130.85;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Assuming a 10% baseline leak rate, ICG prevents one leak per 27 patients treated. Subgroup analysis showed benefit even when ICG did not prompt surgical plan modification (RR 0.67, 95% CI 0.50\u20130.90). Between\u2010study heterogeneity was negligible across all analyses. ICG use did not prolong operating time and has reduced postoperative complications (RR 0.88, 95% CI 0.73\u20131.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intraoperative ICG fluorescence angiography significantly reduces anastomotic leak rates after left\u2010sided colorectal resection, with consistent benefit across diverse surgical settings. The technology is practical and does not prolong operating time. ICG angiography should be considered a valuable adjunct in left\u2010sided colorectal resections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.70378","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:41:07Z","timestamp":1770784867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of intraoperative\n                    <scp>ICG<\/scp>\n                    fluorescence angiography to reduce anastomotic leak in left\u2010sided colorectal resections: A systematic review and meta\u2010analysis of\n                    <scp>RCTs<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9912-5334","authenticated-orcid":false,"given":"Ahmed","family":"Boalot","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Huddersfield Royal Infirmary Calderdale and Huddersfield NHS Foundation Trust  Huddersfield 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Infirmary Calderdale and Huddersfield NHS Foundation Trust  Huddersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Hannah","sequence":"additional","affiliation":[{"name":"Academic and Research Librarian Calderdale and Huddersfield NHS Foundation Trust  Huddersfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneer","family":"Junejo","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Huddersfield Royal Infirmary Calderdale and Huddersfield NHS Foundation Trust  Huddersfield 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reducing anastomotic leakage after laparoscopic colorectal cancer radical surgery","volume":"21","author":"Ren J","year":"2018","journal-title":"Chin J Gastrointes Surg"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.815753"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(04)00087-3"},{"issue":"5","key":"e_1_2_13_41_1","first-page":"395","article-title":"Outcomes following anastomotic leak from rectal resections, including bowel function and quality of life","volume":"39","author":"Di Re A","year":"2022","journal-title":"Ann Coloproctol"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10564-2"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10827-6"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i44.6945"}],"container-title":["Colorectal 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